...-ubiquitinated) proteins and failures in proteasome-dependent degradation. Whereas the distribution of proteasomes and its role in synaptic function have been studied, whether proteasome activity regulates the axonal transport and metabolism of the amyloid precursor protein (APP), remains elusive. By using live...

... ABSTRACT Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here, we have elucidated whether downregulation of septin...

...James R. Edgar; Katarina Willén; Gunnar K. Gouras; Clare E. Futter ABSTRACT Intracellular amyloid-β (Aβ) accumulation is a key feature of early Alzheimer's disease and precedes the appearance of Aβ in extracellular plaques. Aβ is generated through proteolytic processing of amyloid precursor protein...

...S. Ali M. Shariati; Pierre Lau; Bassem A. Hassan; Ulrike Müller; Carlos G. Dotti; Bart De Strooper; Annette Gärtner Summary Expression of amyloid precursor protein (APP) and its two paralogues, APLP1 and APLP2 during brain development coincides with key cellular events such as neuronal...

...Zoë V. Goodger; Lawrence Rajendran; Annette Trutzel; Bernhard M. Kohli; Roger M. Nitsch; Uwe Konietzko Proteolytic processing of the amyloid precursor protein (APP) occurs via two alternative pathways, localized to different subcellular compartments, which result in functionally distinct outcomes...

...Ayae Kinoshita; Hiroaki Fukumoto; Tejal Shah; Christa M. Whelan; Michael C. Irizarry; Bradley T. Hyman Amyloid-β peptide, which accumulates in senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein (APP) by proteolytic processing. β-secretase (Asp2), which cleaves APP...

...Bart De Strooper; Wim Annaert ABSTRACT Recent research has identified some key players involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the amyloid plaques in Alzheimer patients. Interesting parallels exists...