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Keywords: Alternative splicing
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Journal Articles
J Cell Sci (2021) 134 (18): jcs258684.
Published: 17 September 2021
... sarcomere organization and stiffness. The titin gene ( TTN ) is subject to various alternative splicing events, but in the region that is present at the M-line, the only exon that can be spliced out is Mex5, which encodes for the insertion sequence 7 (is7). Interestingly, in the heart, the majority of titin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs251967.
Published: 15 April 2021
... and axon growth. The eukaryotic Ccd42 gene is alternatively spliced to generate mRNAs with two different 3′ untranslated regions (UTRs) that encode proteins with distinct C-termini. The C-termini of these Cdc42 proteins include CaaX and CCaX motifs for post-translational prenylation and palmitoylation...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (4): jcs252957.
Published: 24 February 2021
... Cellular fibronectin (FN; also known as FN1) variants harboring one or two alternatively spliced so-called extra domains (EDB and EDA) play a central bioregulatory role during development, repair processes and fibrosis. Yet, how the extra domains impact fibrillar assembly and function of the molecule...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (8): jcs230201.
Published: 25 April 2019
...Alexander Neumann; Magdalena Schindler; Didrik Olofsson; Ilka Wilhelmi; Annette Schürmann; Florian Heyd ABSTRACT Alternative splicing (AS) strongly increases proteome diversity and functionality in eukaryotic cells. Protein secretion is a tightly controlled process, especially when it occurs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs214379.
Published: 11 June 2018
... biogenesis, not by controlling the transcription of CeHD-related genes, but by affecting the alternative splicing of unc-52 (known as perlecan or HSPG2 in mammals), the predicted basement extracellular matrix (ECM) ligand of CeHDs. CCAR-1 physically interacts with HRP-2 (hnRNPR in mammals), a splicing factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs216465.
Published: 16 May 2018
... how trafficking pathways are fine-tuned for specialized tissue functions in vivo and during development. In parallel, the ENCODE project and numerous genetic studies have revealed that alternative splicing regulates gene expression in tissues and throughout development at a post-transcriptional level...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (4): jcs202002.
Published: 14 February 2018
...) granules. RNP granules assemble through a concentration-dependent liquid–liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain...
Journal Articles
J Cell Sci (2015) 128 (4): 631–637.
Published: 15 February 2015
... ) Competing interests The authors declare no competing or financial interests. 1 08 2014 15 12 2014 © 2015. Published by The Company of Biologists Ltd 2015 Mef2 Muscle differentiation Rbfox Alternative splicing Together with transcriptional control, alternative splicing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4368–4380.
Published: 15 October 2014
... 2014 Astrocytes Neural stem cells Alternative splicing Epigenetics GFAP isoforms In the adult mammalian brain, astrocytes represent the major population of glial cells. Astrocytes are crucial for neuronal support, including synaptic transmission and information processing by neural...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1179–1189.
Published: 15 March 2014
...Sita Subbaram; Scott P. Lyons; Kimberly B. Svenson; Sean L. Hammond; Lorena G. McCabe; Sridar V. Chittur; C. Michael DiPersio ABSTRACT It is unknown how cues from the tumor microenvironment can regulate post-transcriptional mechanisms, such as alternative splicing, that control genes that drive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2466–2477.
Published: 15 May 2012
...Erin A. Greaves; Nikki A. Copeland; Dawn Coverley; Justin F. X. Ainscough CIZ1 is a nuclear-matrix-associated DNA replication factor unique to higher eukaryotes, for which alternatively spliced isoforms have been associated with a range of disorders. In vitro, the CIZ1 N-terminus interacts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4286–4298.
Published: 15 December 2011
... all known types of alternative splicing, the most common being alternative splicing of cassette exons. We confirmed that knockdown of Son leads to exon skipping in pre-mRNAs for chromatin-modifying enzymes, including ADA, HDAC6 and SetD8. This study reports a comprehensive view of human transcription...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 40–50.
Published: 1 January 2010
...Natacha Dreumont; Cyril F. Bourgeois; Fabrice Lejeune; Yilei Liu; Ingrid E. Ehrmann; David J. Elliott; James Stévenin RBMY is a male germline RNA binding protein and potential alternative splicing regulator, but the lack of a convenient biological system has made its cellular functions elusive. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1507–1517.
Published: 15 May 2009
...). Here, we identified and characterized another four claudin-10 splice variants in mouse and human. One (Cldn10a_v1) results from an alternative splice donor site, causing a deletion of the last 57 nucleotides of exon 1a. For each of these three variants one further splice variant was identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 385–393.
Published: 1 February 2007
... Stem cells Alternative splicing The clearest evidence for diversity of TCF/LEF protein activity is arguably from analysis of Xenopus development. Wnt signalling normally functions on the prospective dorsal side of the early embryo, where it is required for induction of dorsal development...
Journal Articles
J Cell Sci (2006) 119 (23): 4944–4951.
Published: 1 December 2006
... of variants. Sequence analysis identified at least six variants that result from alternative splicing and intron retention. Comparison of the results of perlecan RT-PCR analysis with those of analysis of four other genes suggested that the splicing defect in the perlecan gene is unique...
Journal Articles
J Cell Sci (2006) 119 (14): 2995–3007.
Published: 15 July 2006
.... They are predicted to contain ten membrane-spanning segments, two large cytoplasmic loops as well as cytosolic N- and C-termini. Several isoform variants are generated for both PMCA1 and PMCA2 by alternative splicing, affecting their first cytosolic loop (A-site) and their C-terminal tail. To understand how...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2635–2641.
Published: 1 July 2006
...Anabella Srebrow; Alberto R. Kornblihtt Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control of their synthesis is required...
Journal Articles
J Cell Sci (2006) 119 (5): 898–909.
Published: 1 March 2006
... in the developing human central nervous system with a role in oligodendrocyte survival. * Author for correspondence (e-mail: hugo.cabedo@umh.es ) 16 11 2005 © The Company of Biologists Limited 2006 2006 EGF-like Alternative splicing Ubiquitin/proteasome system ErbB4 receptor...
Journal Articles
J Cell Sci (2005) 118 (13): 2923–2933.
Published: 1 July 2005
... in transcripts of mutant DMPK form nuclear foci that recruit muscleblind-like (MBNL) proteins, a family of alternative splicing factors. Although transcripts of mutant DMPK and MBNL proteins accumulate in nuclear RNA foci, it is not clear whether foci formation is required for splicing mis-regulation. Here, we...