1-20 of 50
Keywords: Akt
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2023) 136 (7): jcs260133.
Published: 27 March 2023
...-kinase (PI3K)–Akt pathway. Although some studies have indicated that EGFR signaling may be controlled by signal enrichment within various membrane rafts, such as flotillin nanodomains, others have found a limited effect of disruption of these nanodomains on EGFR signaling, suggesting that specific...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (13): jcs260014.
Published: 13 July 2022
... (K1055, E1056, R1064 and L1065) involved in regulating IGF1R kinase activity could be explored for designing small-molecule allosteric inhibitors for IGF1R. PI3K signaling AKT IGF1R signaling ERK MAPK pathway Allosteric inhibitors Science and Engineering Research Board http...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248898.
Published: 9 December 2020
... also revealed that knockdown of ssc-miR-21-5p impeded the phosphorylation of AKT (herein referring to AKT1) by targeting PDCD4, which further upregulated the expression of Bax, and downregulated the levels of Bcl2 and Mmp9. Furthermore, loss of function of Mus musculus (mmu)-miR-21-5p in vivo resulted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs236505.
Published: 14 November 2019
... activity. Immunoblot (IB) analysis of mTORC2 substrate phospho-AKT S473 (pAKT, AKTS473-P) and AKT substrates (α-P-PKB substrates) in A375 Rictor KO cells transfected with Rictor wt or mutants. AKT phosphorylation is significantly reduced in the Rictor KO A375 cells expressing Rictor G884D , Rictor G934E...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (2): jcs224998.
Published: 24 January 2019
... , macropinocytic cups are organized by ‘macropinocytic patches’ in the plasma membrane. These contain activated Ras, Rac and phospholipid PIP3, and direct actin polymerization to their periphery. We show that a Dictyostelium Akt (PkbA) and an SGK (PkbR1) protein kinase act downstream of PIP3 and, together...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs220517.
Published: 16 November 2018
... phosphorylation of Akt. To test the hypothesis that CDRs increase synthesis of phosphorylated Akt1 (pAkt), we analyzed the contributions of CDRs to Akt phosphorylation in response to PDGF and EGF. CDRs appeared within several minutes of growth factor addition, coincident with a peak of pAkt. Microtubule...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs216168.
Published: 29 October 2018
... was dramatically increased following CAMSAP3 removal, leading to the upregulation of Akt proteins (also known as protein kinase B proteins, hereafter Akt) activity, which is known to promote EMT. These findings suggest that CAMSAP3 functions to protect lung carcinoma cells against EMT by suppressing Akt activity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs212076.
Published: 6 August 2018
... required for differentiation, includeing mTOR-dependent Akt activation but not Erk1/2 activation. We identify N-myc downstream regulated gene-1 (NDRG1) as a PTPα-regulated molecule during oligodendrocyte differentiation, and distinguish Lm2 receptor-specific modes of Fyn–Akt-dependent and -independent...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (14): 2394–2404.
Published: 15 July 2017
... development by increasing expression of the cell–cell adhesion molecule CsA (also known as CsaA) and causing aggregation, and this effect, as well as the inhibition of proteasome activity, is mediated by Ras and Akt proteins. Surprisingly, Ras and Akt do not affect the ability of polyphosphate to inhibit...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (6): 1169–1178.
Published: 15 March 2017
... kinase and flippase. Akt Rho Flippase Phosphatidylserine Membrane stress Actin cytoskeleton The plasma membrane (PM) frequently suffers from physical stress, including turgor pressure caused by imbalanced osmolality and membrane stretching/shrinking caused by muscle contraction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (16): 3153–3166.
Published: 15 August 2016
... transition in oocytes is essential for reproduction. However, the mechanism for threshold establishment is unclear. In starfish oocytes, maturation-inducing hormones activate the PI3K–Akt pathway through the G βγ complex of heterotrimeric G-proteins. Akt directly phosphorylates both Cdc25 phosphatase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 2052–2063.
Published: 15 May 2016
...Sean M. Gross; Peter Rotwein ABSTRACT Growth factors alter cellular behavior through shared signaling cascades, raising the question of how specificity is achieved. Here, we have determined how growth factor actions are encoded into Akt signaling dynamics by real-time tracking of a fluorescent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1165–1178.
Published: 15 March 2016
... has been hampered by side effects such as elevated vascular permeability. Here, we attempted to induce endothelial cell elongation without an overdose of VEGF. By screening a library of chemical inhibitors, we identified phosphatidylinositol 3-kinase (PI3K)–Akt pathway inhibitors and mammalian target...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3456–3465.
Published: 15 September 2015
...Nirmal Jethwa; Gary H. C. Chung; Marta G. Lete; Alicia Alonso; Richard D. Byrne; Véronique Calleja; Banafshé Larijani ABSTRACT PKB/Akt activation is a common step in tumour growth, proliferation and survival. Akt activation is understood to occur at the plasma membrane of cells in response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2497–2508.
Published: 15 July 2015
.... , Park , E. K. and Kang , S.-S. ( 2000 ). Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells . Biochem. Biophys. Res. Commun.   278 , 306 - 311 . 10.1006/bbrc.2000.3805 Beauchamp , E. M. and Platanias , L. C...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2509–2519.
Published: 15 July 2015
...Sean M. Gross; Peter Rotwein ABSTRACT The protein kinase Akt (for which there are three isoforms) is a key intracellular mediator of many biological processes, yet knowledge of Akt signaling dynamics is limited. Here, we have constructed a fluorescent reporter molecule in a lentiviral delivery...
Includes: Supplementary data