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Keywords: Agrin
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Journal Articles
J Cell Sci (2018) 131 (15): jcs215251.
Published: 10 August 2018
...://www.biologists.com/user-licence-1-1/ Summary: Rac1 activation promotes both the initial formation of AChR clusters as well as the dispersal of pre-existing clusters, whereas Rac1 inhibition is required to stabilize clusters. Neuromuscular junction Acetylcholine receptor Agrin Rho GTPase Rac1...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2000) 113 (16): 2877–2886.
Published: 15 August 2000
... as neural agrin, can induce AChR clustering in C2C12 myofibers. We recently showed that specific isoforms of the α7β1 integrin (a receptor normally found at neuromuscular junctions) colocalize and physically interact with AChR clusters in a laminin-dependent fashion. In contrast, induction with agrin alone...
Journal Articles
J Cell Sci (1999) 112 (24): 4729–4738.
Published: 15 December 1999
...Adriana Ferreira ABSTRACT Agrin, a 200 kDa extracellular matrix protein, participates in the maturation of the postsynaptic target at the neuromuscular junction. Although agrin has also been detected in central neurons, little is known about its role in the formation of their synapses...
Journal Articles
Journal Articles
J Cell Sci (1998) 111 (17): 2595–2605.
Published: 1 September 1998
... clustering in cultured muscle cells, we examined the role of α-dystrobrevin during synapse formation and in response to agrin. Using specific antibodies, we show that C2 myoblasts and early myotubes only produce α-dystrobrevin-1, the mammalian orthologue of Torpedo dystrobrevin, whereas mature skeletal...
Journal Articles
J Cell Sci (1996) 109 (13): 2959–2966.
Published: 15 December 1996
...Gérard Escher; Catherine Béchade; Sabine Levi; Antoine Triller ABSTRACT Agrin, a synaptic basal lamina protein synthesized by motoneurons is involved in the aggregation of nicotinic acetylcholine receptors (nAchRs) at the neuromuscular junction. Agrin transcripts are broadly expressed...
Journal Articles