1-20 of 21
Keywords: Aggresome
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Proteostasis
J Cell Sci (2021) 134 (7): jcs254201.
Published: 15 April 2021
... proteinopathies; however, the precise defects underlying these disorders are unclear. Here, we systematically investigate the role of p97 and its adaptors in the process of formation of aggresomes, membrane-less structures containing ubiquitylated proteins that arise upon proteasome inhibition. We demonstrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs216507.
Published: 5 December 2018
... is a determinant factor in the oscillation of AGS3 among different subcellular compartments and protein phase transitions. Activators of G-protein signaling 3 G-protein regulatory domain Cytosolic puncta Phosphorylation Phase transition Aggresome National Institutes of Health 10.13039...
Journal Articles
In collection:
Proteostasis
J Cell Sci (2018) 131 (14): jcs216671.
Published: 26 July 2018
...Chenliang Zhang; Ju Gao; Mengen Li; Yongkang Deng; Changan Jiang ABSTRACT Aggresome formation is a major strategy to enable cells to cope with proteasomal stress. Misfolded proteins are assembled into micro-aggregates and transported to the microtubule organizing center (MTOC) to form perinuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (19): 3635–3647.
Published: 1 October 2016
... as ‘aggresomes’. The roles of aggresomes as cellular quality control centers, and the cellular origin of the deposits contained within these structures, remain to be characterized. Here, we utilized the observation that the prion protein (PrP, also known as PRNP) accumulates in aggresomes following...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (18): 4173–4186.
Published: 15 September 2013
...Zhe Xu; Kourtney Graham; Molly Foote; Fengshan Liang; Raed Rizkallah; Myra Hurt; Yanchang Wang; Yuying Wu; Yi Zhou Summary The aggresome is a key cytoplasmic organelle for sequestration and clearance of toxic protein aggregates. Although loading misfolded proteins cargos to dynein motors has been...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Proteostasis
J Cell Sci (2012) 125 (11): 2665–2674.
Published: 1 June 2012
...Anatoli B. Meriin; Nava Zaarur; Michael Y. Sherman Aggresome formation is initiated upon proteasome failure, and facilitates autophagic clearance of protein aggregates to protect cells from proteotoxicity. Here we demonstrate that proteasome inhibition generates a signaling event to trigger...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (16): 2692–2701.
Published: 15 August 2011
...Yoshihisa Watanabe; Masaki Tanaka Proteolytic systems and the aggresome pathway contribute to preventing accumulation of cytotoxic aggregation-prone proteins. Although polyubiquitylation is usually required for degradation or aggresome formation, several substrates are processed independently...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1891–1902.
Published: 1 June 2011
... have been found to accumulate in juxtanuclear deposition sites termed ‘aggresomes’. Recently, it was shown that cells can contain at least two types of deposition sites for misfolded proteins: a dynamic quality-control compartment, which was termed ‘JUNQ’, and a site for terminally aggregated proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (9): 1519–1532.
Published: 1 May 2011
...Masahiko Watabe; Toshio Nakaki Misfolded protein aggregates elicit a stress response, and their clearance is crucial for cell survival. These aggregates are transported by cytoplasmic deacetylase HDAC6 and dynein motors to the aggresome via the microtubule network, and are removed by autophagic...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
J Cell Sci (2008) 121 (24): 4079–4088.
Published: 15 December 2008
...Birte Kalveram; Gunter Schmidtke; Marcus Groettrup During misfolded-protein stress, the cytoplasmic protein histone deacetylase 6 (HDAC6) functions as a linker between the dynein motor and polyubiquitin to mediate the transport of polyubiquitylated cargo to the aggresome. Here, we identify a new...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1415–1425.
Published: 1 May 2008
... nucleator Arp2/3. This aggregate was tightly associated with the Golgi complex and mitochondria, and was surrounded by vimentin intermediate filaments, microtubules and MAP4. Therefore, the Jpk-induced single, large F-actin aggregate fits the established criteria for being considered an aggresome. Lysosomes...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (25): 6249–6259.
Published: 1 December 2004
.../p25 inhibited cell division and promoted cell death. At high expression levels or in the presence of proteosome inhibitor, green fusion protein accumulated around centrosomes forming an aggresome-like structure protruding into the nucleus or a filamentous cage of microtubules surrounding the nucleus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (18): 4239–4251.
Published: 15 August 2004
... 2004 Aggresome Atg5 Autophagy BEACH domain FYVE domain PI-3-kinase Phosphoinositides, phosphorylated derivatives of the membrane lipid phosphatidylinositol, regulate cytoskeleton function, membrane trafficking and receptor signalling through reversible recruitment of protein complexes...
Journal Articles
In collection:
Proteostasis
J Cell Sci (2004) 117 (2): 281–292.
Published: 15 January 2004
... proteins accumulated as dispersed aggregates rather than as single aggresomes, even in the presence of proteasome inhibitors, which normally promote aggresome formation. RNAi of VCP caused extensive vacuolization of the cytoplasm, and proteasome inhibitors exaggerated this feature. RNAi of VCP had little...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (19): 4011–4019.
Published: 1 October 2003
... of Biologists Limited 2003 2003 Parkin Centrosome Aggresome γ-Tubulin Parkinson's disease Parkinson's disease (PD) is a neurodegenerative disorder resulting from the selective loss of dopamine (DA) neurons in substantia nigra pars compacta (SNpc). The degeneration of these neurons is thought...
Journal Articles
J Cell Sci (2003) 116 (15): 3109–3121.
Published: 1 August 2003
... in juxtanuclear aggregates meeting the main criterions of aggresomes and leading to profound alterations of the mitochondrial network. The viability of cells transfected by intracellular forms of clusterin was improved by overexpression of Bcl-2,and caspase inhibition was capable of rescuing cells expressing...
Journal Articles