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1-15 of 15
Keywords: Aggregation
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Journal Articles
Toxicity of the model protein 3×GFP arises from degradation overload, not from aggregate formation
Open AccessIn collection:
Proteostasis
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (11): jcs261977.
Published: 12 June 2024
...Shotaro Namba; Hisao Moriya ABSTRACT Although protein aggregation can cause cytotoxicity, such aggregates can also form to mitigate cytotoxicity from misfolded proteins, although the nature of these contrasting aggregates remains unclear. We previously found that overproduction (op) of a three...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Shinjinee Sengupta, Namrata Singh, Ajoy Paul, Debalina Datta, Debdeep Chatterjee, Semanti Mukherjee, Laxmikant Gadhe, Jyoti Devi, Yeshwanth Mahesh, Mohit Kumar Jolly, Samir K. Maji
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (17): jcs261017.
Published: 8 September 2023
... (also known as TP63 and TP73, respectively) protein in higher-grade tumor tissues. The data suggest p53 misfolding and/or aggregation, and subsequent amyloid formation, lead to loss of the tumor-suppressive function and the gain of oncogenic function, aggravation of which might determine the cancer...
Includes: Supplementary data
Journal Articles
Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments
FreeTziona Ben-Gedalya, Roman Lyakhovetsky, Yifat Yedidia, Michal Bejerano-Sagie, Natalya M. Kogan, Marcela Viviana Karpuj, Daniel Kaganovich, Ehud Cohen
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (11): 1891–1902.
Published: 1 June 2011
... insoluble aggregates. In some cases, protein aggregation leads to the development of human neurodegenerative maladies, including Alzheimer's and prion diseases. Aggregates of misfolded prion protein (PrP), which appear in cells after exposure to the drug cyclosporin A (CsA), and disease-linked PrP mutants...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (18): 3262–3271.
Published: 15 September 2009
... of these proteins containing the expanded polyQ tract are thought to initiate aggregation and represent the toxic species. Although it is not clear how these toxic fragments are generated, in vitro data suggest that proteasomes are unable to digest polyQ tracts. To examine whether the resulting polyQ peptides could...
Includes: Supplementary data
Journal Articles
Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin
Available to PurchaseJeanne Shepshelovich, Lee Goldstein-Magal, Anat Globerson, Paul M. Yen, Pnina Rotman-Pikielny, Koret Hirschberg
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (8): 1577–1586.
Published: 15 April 2005
...Jeanne Shepshelovich; Lee Goldstein-Magal; Anat Globerson; Paul M. Yen; Pnina Rotman-Pikielny; Koret Hirschberg An outcome of overloading of the endoplasmic reticulum (ER) folding machinery is a perturbation in ER function and the formation of intracellular aggregates. The latter is a key...
Includes: Multimedia, Supplementary data
Journal Articles
PG-M/versican binds to P-selectin glycoprotein ligand-1 and mediates leukocyte aggregation
Available to PurchasePeng-Sheng Zheng, Dana Vais, David LaPierre, Yao-Yun Liang, Vivian Lee, Bing L. Yang, Burton B. Yang
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (24): 5887–5895.
Published: 15 November 2004
... that PSGL-1 binds to the C-terminal (G3 domain) of the extracellular proteoglycan PG-M/versican. Cells transfected with PSGL-1 or a shorter form containing the binding site, or cells expressing endogenous PSGL-1 aggregate in the presence of versican or G3 product. The aggregation appears to be induced by G3...
Journal Articles
Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (23): 5681–5686.
Published: 1 November 2004
...Takashi Hamazaki; Masahiro Oka; Shinya Yamanaka; Naohiro Terada When embryonic stem cells are allowed to aggregate, the outer layer of the aggregated spheres (referred to as embryoid bodies) differentiates into primitive endoderm. This initial specification of cell lineage facilitates further...
Journal Articles
Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (21): 5133–5143.
Published: 1 October 2004
... to aggregate and these enlarged yolk platelets fill the cytoplasm of cpl-1 mutant embryos. Coincident with this aggregation is loss of fluorescence from a yolk green fluorescent protein (YP170::GFP). This suggests that loss of CPL-1 activity leads to aberrant processing and/or conformational changes in yolk...
Journal Articles
Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons
Available to PurchaseAnirban R. Saha, Josephine Hill, Michelle A. Utton, Ayodeji A. Asuni, Steven Ackerley, Andrew J. Grierson, Christopher C. Miller, Alun M. Davies, Vladimir L. Buchman, Brian H. Anderton, Diane P. Hanger
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (7): 1017–1024.
Published: 1 March 2004
... familial autosomal dominant Parkinson's disease. One explanation for the formation of perikaryal and neuritic aggregates of α-synuclein, which is a presynaptic protein, is that the mutations disrupt α-synuclein transport and lead to its proximal accumulation. We found that mutant forms of α-synuclein...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (6): 861–869.
Published: 22 February 2004
...F. Fasani; A. Bocquet; P. Robert; A. Peterson; J. Eyer Neurofilaments are synthesised and assembled in neuronal cell bodies, transported along axons and degraded at the synapse. However, in several pathological situations they aggregate in cell bodies or axons. To investigate their turnover when...
Journal Articles
Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1997) 110 (16): 1867–1877.
Published: 15 August 1997
... molecular clusters. Moreover, a close correlation was observed between the fate of crosslinked proteins, including the TfR and acetylcholinesterase (AChE), and the fate of the clustered lipid N-Rh-PE. Thus antibody-induced aggregation of specific proteins like the TfR and AChE, which are normally sorted...
Journal Articles
E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1997) 110 (3): 345–356.
Published: 1 February 1997
... or activity of E-cadherin expressed. All of the lines showed levels of calcium-dependent aggregation that were similar to that of ELs8 cells and immunoblot analyses indicated that the amount of mouse E-cadherin expressed by several cells that did not show reduced invasion was comparable to that expressed...
Journal Articles
Differential targeting of recombinant fibronectins in AtT-20 cells based on their efficiency of aggregation
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (12): 3827–3837.
Published: 1 December 1995
... protein synthesis. Presence of the organelles correlates with intracellular aggregation of dimeric fibronectin polypeptides. The organelles are absent in cells expressing monomeric recombinant fibronectin (lacking C-terminal dimerization sites) or the C-terminal half of fibronectin (which dimerizes...
Journal Articles
Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (11): 3183–3190.
Published: 1 November 1994
.... The CD44Epican -transfected L cells acquired: (a) a selfaggregating phenotype that required hyaluronan but was calcium-independent; and (b) a new capacity to adhere to keratinocytes, a property that was blocked by an antiepican antibody. Both aggregation and adhesion of CD44Epican -transfected cells were...
Journal Articles
Salmonella typhimurium induces selective aggregation and internalization of host cell surface proteins during invasion of epithelial cells
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (7): 2005–2020.
Published: 1 July 1994
.... typhimurium invasion of epithelial cells. Entry of S. typhimurium into HeLa epithelial cells produced extensive aggregation of cell surface class I MHC heavy chain, β 2 -microglobulin, fibronectin-receptor (α 5 β 1 integrin), and hyaluronate receptor (CD-44). Other cell surface proteins such as transferrin...