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Proteostasis
J Cell Sci (2021) 134 (7): jcs254201.
Published: 15 April 2021
... to a variety of protein aggregation disorders broadly termed proteinopathies. The AAA-ATPase p97 (also known as VCP), in combination with adaptor proteins, functions to identify ubiquitylated proteins and target them for degradation by the proteasome or through autophagy. Mutations in p97 cause multi-system...
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Journal Articles
J Cell Sci (1999) 112 (13): 2099–2112.
Published: 1 July 1999
...-crystallin has been identified as the genetic basis of desmin related myopathy. This disease is characterised in its pathology by aggregates of intermediate filaments associated with αB-crystallin. Here we report that HSP27 like αB-crystallin is associated with glial fibrillary acidic protein and vimentin...