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Francesca Pala, Daniela Di Girolamo, Sébastien Mella, Siham Yennek, Laurent Chatre, Miria Ricchetti, Shahragim Tajbakhsh
J Cell Sci (2018) 131 (14): jcs212977.
Published: 27 July 2018
... and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem cells have low energetic demands and perturbed oxidative phosphorylation during ageing, which is also the case for cells from post-mortem tissues. We show also...
Includes: Supplementary data
Jacob A. Ross, Richard G. Webster, Tanguy Lechertier, Louise E. Reynolds, Mark Turmaine, Maximilien Bencze, Yalda Jamshidi, Hakan Cetin, Francesco Muntoni, David Beeson, Kairbaan Hodilvala-Dilke, Francesco J. Conti
J Cell Sci (2017) 130 (10): 1772–1784.
Published: 15 May 2017
... integrity of the synapse – mutant NMJs present with progressive structural changes and upregulated autophagy, features commonly observed during ageing and in models of neurodegeneration. Unexpectedly, we find instances of nerve terminal detachment from the muscle fibre; to our knowledge, this is the first...
Includes: Supplementary data
J Cell Sci (2012) 125 (21): 4963–4971.
Published: 01 November 2012
... by PGC1α contribute to an increase in oxidative metabolism and the preservation of ROS homeostasis. Finally, we examine the importance of these findings in ageing and neurodegenerative disorders, conditions that are associated with impaired mitochondrial functions and ROS balance. Box 2. Respiration...
J Cell Sci (2011) 124 (9): 1363–1372.
Published: 01 May 2011
... that are involved in a wide range of cellular processes during all stages of life, from development to ageing, and during homeostasis and stress. This Commentary discusses some lesser-known functional and regulatory aspects of IFs. We specifically address the emerging roles of nestin in myogenesis and cancer cell...
J Cell Sci (2005) 118 (20): 4813–4821.
Published: 15 October 2005
.../unit length decreases in larger fibres during skeletal muscle ageing. This leads to an increased size of nuclear domain (quantity of cytoplasm/number of nuclei within that cytoplasm). Initially, larger fibres have more satellite cells than small fibres, but this advantage is lost as satellite cells...
David J. Kurz, Stephanie Decary, Ying Hong, Elisabeth Trivier, Alexander Akhmedov, Jorge D. Erusalimsky
J Cell Sci (2004) 117 (11): 2417–2426.
Published: 01 May 2004
...David J. Kurz; Stephanie Decary; Ying Hong; Elisabeth Trivier; Alexander Akhmedov; Jorge D. Erusalimsky Replicative senescence and oxidative stress have been implicated in ageing, endothelial dysfunction and atherosclerosis. Replicative senescence is determined primarily by telomere integrity...
Terence Davis, Sim K. Singhrao, Fiona S. Wyllie, Michele F. Haughton, Paul J. Smith, Marie Wiltshire, David Wynford-Thomas, Christopher J. Jones, Richard G. A. Faragher, David Kipling
J Cell Sci (2003) 116 (7): 1349–1357.
Published: 01 April 2003
... this has been thought to be causal in the accelerated ageing of this disease, controversy remains as to whether Werner syndrome is showing the acceleration of a normal cellular ageing mechanism or the occurrence of a novel Werner-syndrome-specific process. Here,we analyse the signalling pathways...