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Keywords: Ageing
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Journal Articles
In collection:
Adhesion , Polarity
J Cell Sci (2023) 136 (19): jcs261118.
Published: 5 October 2023
.... In invertebrates, these functions depend on formation and maintenance of ‘tight’ septate junctions (SJs). However, the mechanism by which SJs affect transport competence and tissue homeostasis, and how these are modulated by ageing, remain incompletely understood. Here, we demonstrate that the Drosophila renal...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2018) 131 (14): jcs212977.
Published: 27 July 2018
... and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem cells have low energetic demands and perturbed oxidative phosphorylation during ageing, which is also the case for cells from post-mortem tissues. We show also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1772–1784.
Published: 15 May 2017
... integrity of the synapse – mutant NMJs present with progressive structural changes and upregulated autophagy, features commonly observed during ageing and in models of neurodegeneration. Unexpectedly, we find instances of nerve terminal detachment from the muscle fibre; to our knowledge, this is the first...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 4963–4971.
Published: 1 November 2012
... by PGC1α contribute to an increase in oxidative metabolism and the preservation of ROS homeostasis. Finally, we examine the importance of these findings in ageing and neurodegenerative disorders, conditions that are associated with impaired mitochondrial functions and ROS balance. * Author...
Journal Articles
J Cell Sci (2011) 124 (9): 1363–1372.
Published: 1 May 2011
... that are involved in a wide range of cellular processes during all stages of life, from development to ageing, and during homeostasis and stress. This Commentary discusses some lesser-known functional and regulatory aspects of IFs. We specifically address the emerging roles of nestin in myogenesis and cancer cell...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1998) 111 (16): 2297–2303.
Published: 15 August 1998
...K. Martin; C. S. Potten; S. A. Roberts; T. B. L. Kirkwood ABSTRACT Ageing is associated with a progressive deterioration in the functions of many organs within the body. In tissue with high cell turnover, the maintenance of the stem cells is of particular importance. Any accumulation of damage...