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Keywords: Adherens junctions
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Journal Articles
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (4): jcs258929.
Published: 22 February 2022
...Chaoyu Fu; Aditya Arora; Wilfried Engl; Michael Sheetz; Virgile Viasnoff ABSTRACT The mechanisms controlling the dynamics of expansion of adherens junctions are significantly less understood than those controlling their static properties. Here, we report that for suspended cell aggregates, the time...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs206896.
Published: 12 February 2018
... 2018 Summary: Calcium signaling leads a morphogenetic process during neural rosette formation by regulating the movement of cell cytoskeletal elements. Embryonic stem cells Neural stem cell niche Neural rosette formation Calcium Neurogenesis Adherens junctions Cytoskeleton proteins...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Mechanobiology
J Cell Sci (2018) 131 (3): jcs208736.
Published: 5 February 2018
... remaining sufficiently plastic to allow events such as cytokinesis to take place is a key biological problem. In vertebrates, the remodelling and reinforcement of adherens junctions maintains epithelial integrity during cytokinesis. The involvement of tight junctions in cell division, however, has remained...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs207605.
Published: 10 January 2018
... examined vascular permeability in EC-specific Rap1A- and Rap1B-knockout mice, cell–cell junction remodeling and EC monolayer resistivity in Rap1-deficient ECs under basal, inflammatory or elevated VEGF conditions. Deletion of either Rap1 isoform impaired de novo adherens junction (AJ) formation...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2016) 129 (19): 3583–3596.
Published: 1 October 2016
... GAP domain, we demonstrate that DLC3 activity locally regulates RhoA–ROCK signaling at and Scribble localization to adherens junctions, and is required for their functional integrity. In a 3D model of cyst development, we furthermore show that DLC3 depletion impairs polarized morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2047–2056.
Published: 1 June 2015
...Shinichiro Nakahara; Koji Tsutsumi; Takuya Zuinen; Yasutaka Ohta ABSTRACT Rho family small GTPases are essential for the formation of adherens junctions in epithelial cells. Here, we found that FilGAP (also known as ARHGAP24), a Rac-specific Rho GTPase-activating protein, promoted the formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 878–887.
Published: 1 March 2015
... Endothelium Sphingosine-1-phosphate receptor-1 Tyrosine phosphorylation Serine phosphorylation Endothelial barrier function Adherens junctions Sphingosine-1-phosphate receptor-1 (S1PR1) is a high affinity G-protein-coupled receptor (GPCR) ligated by the lipid mediator S1P ( Hla, 2004 ; Spiegel...
Journal Articles
J Cell Sci (2014) 127 (24): 5127–5137.
Published: 15 December 2014
...Stéphanie Le Bras; Roland Le Borgne ABSTRACT Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed...
Journal Articles
J Cell Sci (2014) 127 (12): 2627–2638.
Published: 15 June 2014
...Stella Alimperti; Hui You; Teresa George; Sandeep K. Agarwal; Stelios T. Andreadis ABSTRACT Although soluble factors, such as transforming growth factor β1 (TGF-β1), induce mesenchymal stem cell (MSC) differentiation towards the smooth muscle cell (SMC) lineage, the role of adherens junctions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2507–2517.
Published: 1 June 2014
...Andrew R. Harris; Alicia Daeden; Guillaume T. Charras ABSTRACT Adherens junctions and desmosomes integrate the cytoskeletons of adjacent cells into a mechanical syncitium. In doing so, intercellular junctions endow tissues with the strength needed to withstand the mechanical stresses encountered...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2420–2432.
Published: 1 June 2014
... RPTPα (human gene name PTPRA ) is recruited to epithelial adherens junctions at the time of cell–cell contact, where it is in molecular proximity to E-cadherin. RPTPα is required for appropriate cadherin-dependent adhesion and for cyst architecture in three-dimensional culture. Loss of RPTPα impairs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1660–1671.
Published: 15 April 2014
...-cadherin-mediated contacts by their plus ends, and that they are involved in a negative-feedback loop with the formation of cell–cell contacts in myogenic cells. Although MTs can associate with adherens junctions through their minus ends in epithelial cells ( Meng et al., 2008 ), the attraction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (12): 2718–2729.
Published: 15 June 2013
...Hui You; Roshan M. Padmashali; Aishwarya Ranganathan; Pedro Lei; Nomeda Girnius; Roger J. Davis; Stelios T. Andreadis Summary We demonstrate that c-Jun N-terminal kinase (JNK) responds to substrate stiffness and regulates adherens junction (AJ) formation in epithelial cells in 2D cultures and in 3D...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2803–2809.
Published: 15 August 2010
... form adherens junctions (AJs) but completely lack tight junctions (TJs) – fully activated SRF. By contrast, AGS gastric adenocarcinoma epithelial cells, which form TJs but are deficient in E-cadherin, and therefore also in AJs, failed to activate SRF. The introduction of wild-type E-cadherin in AGS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1073–1080.
Published: 1 April 2010
... polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5 ) are required for endothelial apicobasal polarity in vitro and during embryonic development. Silencing of CDH5 gene expression leads to abrogation of endothelial polarity accompanied by strong alterations in lumenal structure. VEC co...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 567–577.
Published: 15 February 2010
...Xiao Peng; Laura E. Cuff; Cort D. Lawton; Kris A. DeMali Vinculin was identified as a component of adherens junctions 30 years ago, yet its function there remains elusive. Deletion studies are consistent with the idea that vinculin is important for the organization of cell-cell junctions. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2115–2122.
Published: 1 July 2008
..., ischemia and diabetes – which leads to severe, and sometimes fatal, organ dysfunction. Endothelial permeability is regulated in part by the dynamic opening and closure of cell-cell adherens junctions (AJs). In endothelial cells, AJs are largely composed of vascular endothelial cadherin (VE-cadherin...
Journal Articles
J Cell Sci (2007) 120 (21): 3870–3882.
Published: 1 November 2007
... MCF7 epithelial cells disrupts adherens junctions, as manifested by the significantly decreased localization of E-cadherin and associated proteins to cell-cell contacts. Expression of mouse Dia1, which is insensitive to the human Dia1-specific shRNA, rescued the junctional integrity. Coexpression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3099–3110.
Published: 1 September 2007
.... Exo84 activity is essential for the apical localization of the Crumbs transmembrane protein, a key determinant of epithelial apical identity. Adherens junction proteins become mislocalized at the cell surface in Exo84 mutants in a pattern characteristic of defects in apical, but not basolateral...
Includes: Supplementary data