... or financial interests. © 2015. Published by The Company of Biologists Ltd 2015 DNA damage checkpoints Recovery Competence Adaptation Wip1 Plk1 The current dogma is that the DNA damage response (DDR) affects proliferation such that the DDR can reversibly arrest cell cycle progression...

... with PI3-kinase inhibitor induced an adaptation of Rac1 activity, i.e. a transient reduction of Rac1 activity followed by recovery to the basal level. In silico modeling that reproduced the adaptation predicted the existence of a negative feedback loop from Rac1 to actin polymerization. Finally, we...

...Do Kyun Kim; Eun Sook Cho; Je Kyung Seong; Hong-Duck Um Low levels of H 2 O 2 can induce cellular resistance to subsequent higher levels of H 2 O 2 . By using human U937 leukemia cells, it was previously shown that such an adaptive response can be induced without increasing the cellular capacity...

...R. H. McDermott; M. Butler ABSTRACT Two cell lines (McCoy and MDCK) were studied in an attempt to understand the metabolic changes associated with adaptation to glutamine-free medium (GMEM gmate). McCoy cells assumed normal growth rates after 2-3 passages in this medium whereas MDCK cells showed...

...T. Hassell; M. Butler ABSTRACT Methods for the adaptation of three animal cell lines to media in which glutamine is replaced with either glutamate or 2-oxoglutarate are described. The cell Unes differ in their rate of adaptation. The consequences of the adaptation of the McCoy cell line...

...M. E. E. Ludérus; M. J. Spijkers; R. Van Driel ABSTRACT In developing Dictyostelium discoideum cells, binding of cyclic AMP to the chemotactic receptor has been shown to oscillate. These oscillations represent cycles of activation, adaptation and deadaptation of the cyclic AMP receptor system. We...

...Nadine V. Small; G. Nicholas Europe-Finner; Peter C. Newell ABSTRACT Amoebae of Dictyostelium discoideum show adaptation towards a chemotactic cyclic AMP signal. Within a few seconds of receipt of the signal they are inhibited for a period of 1–2 min from further chemotactic responses to subsequent...