...Zachary McDargh; Tianyi Zhu; Hongkang Zhu; Ben O'Shaughnessy ABSTRACT In common with other actomyosin contractile cellular machineries, actin turnover is required for normal function of the cytokinetic contractile ring. Cofilin is an actin-binding protein contributing to turnover by severing actin...

... and disrupted AJCs, and downregulated actin turnover represented by enhanced levels of phosphorylated cofilin. Thus, Cdc42 influenced the maintenance of stable actin structures through elaborate tuning of actin turnover, and maintained function and viability of cochlear hair cells. * These authors...

.... Biological functions of CAP. Fig. 4. Biological functions of CAP. [email protected] © 2013. Published by The Company of Biologists Ltd 2013 Actin turnover ADF/cofilin Cyclase-associated protein Nucleotide exchange Severing The coordinated regulation of the assembly...

... muscle. * Author for correspondence ( [email protected] ) 9 5 2012 © 2012. Published by The Company of Biologists Ltd 2012 Actin turnover ADF/cofilin Cyclase-associated protein Myofibril Muscle In striated muscle, actin filaments are organized in sarcomeric structures...

... in vivo functions are unclear. In this study, we characterized twf -null mutants in a metazoan for the first time and found that Drosophila twf negatively regulates F-actin formation in subcellular regions of rapid actin turnover in three different systems, namely postsynaptic neuromuscular junction (NMJ...

... phosphoprotein (VASP) Ena/VASP family Serine/threonine kinase Actin turnover In cells, actin-filament-based structures control diverse activities such as polarized intracellular trafficking, cytokinesis, migration and adhesion ( Mitchison and Cramer, 1996 ; Vasioukhin et al., 2000 ). Although...