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Keywords: Actin polymerization
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Journal Articles
J Cell Sci (2019) 132 (24): jcs232355.
Published: 13 December 2019
... to enhance vesicle fission by modifying the lipid environment. PKD also phosphorylates the actin regulatory protein cortactin at S298 to impair synergistic actin polymerization. We here report additional functions for PKD2 (also known as PRKD2) and cortactin in the regulation of actin polymerization during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs230508.
Published: 18 July 2019
... adhesion and the development of cell-mediated cytotoxicity. NK cell Cytotoxicity Actin polymerization EVL Natural killer (NK) cells are innate immune cells responsible for removing abnormal cells on a cell-by-cell basis. During NK cell activation, the NK cell strongly adheres to target...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs210310.
Published: 29 January 2018
... and are specifically localized in the space between the chloroplast and the plasma membrane, and is called chloroplast-actin. In addition, several of the genes that encode proteins that are involved in chloroplast-actin polymerization or maintenance have been identified. In this Review, we discuss the mechanisms...
Journal Articles
Journal Articles
In collection:
Lipid biology
J Cell Sci (2013) 126 (9): 2069–2078.
Published: 1 May 2013
.... , Schulberg   K. L. , Trabosh   V. A. , Kolnik   S. E. , Burns   A. R. , McPartland   K. J. ( 2002 ). Wound closure in the lamellipodia of single cells: mediation by actin polymerization in the absence of an actomyosin purse string.   Mol. Biol. Cell   13 , 1001 – 1014 . 10.1091/mbc.01-04...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4518–4531.
Published: 1 October 2012
... polymerization were attenuated by overexpression of BCR in hippocampal neurons. Knockdown of BCR using specific shRNAs increased the dendritic arborization as well as actin polymerization. The number of dendrites in null mutant BCR −/− mice was considerably increased compared with that in wild-type mice. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4435–4444.
Published: 1 October 2012
... discuss how cell surface dynamics depend on the orchestration of the cytoskeleton and the plasma membrane by Rho GTPases. * Author for correspondence ( meldolesi.jacopo@hsr.it ) © 2012. Published by The Company of Biologists Ltd 2012 Actin polymerization Exocytosis Endocytosis Membrane...
Journal Articles
J Cell Sci (2012) 125 (7): 1666–1672.
Published: 1 April 2012
... polymerization of actin filaments and their association with α-actinin. Only then is a local increase in integrin β3 levels apparent in the podosome ring domain. Thus, local actin polymerization in cortactin- and paxillin-rich locations nucleates podosome assembly before the local accumulation of β3 integrin. We...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3441–3454.
Published: 1 October 2009
... studies have revealed several mechanisms that Abl-family kinases use to mediate these effects. Abl-family kinases stimulate actin polymerization through the activation of cortactin, hematopoietic lineage cell-specific protein (HS1), WASp- and WAVE-family proteins, and Rac1. They also attenuate cell...
Journal Articles
J Cell Sci (2008) 121 (17): 2795–2804.
Published: 1 September 2008
...Hiroaki Hirata; Hitoshi Tatsumi; Masahiro Sokabe We examined the effects of mechanical forces on actin polymerization at focal adhesions (FAs). Actin polymerization at FAs was assessed by introducing fluorescence-labeled actin molecules into permeabilized fibroblasts cultured on fibronectin. When...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1803–1814.
Published: 1 June 2008
..., inhibition of myosin II induced the outgrowth of F-actin-rich surface protrusions. The development of these protrusions was abrogated after inhibition of F-actin polymerization or of phospholipase C (PLC) activity, as well as after overexpression of a dominant-negative ADF/cofilin. Surface protrusions were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (21): 3870–3882.
Published: 1 November 2007
..., A. and Parkos, C. A. ( 2005 ). Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol. Biol. Cell 16 , 2636 -2650. Ivanov, A. I., McCall, I. C., Babbin, B., Samarin, S. N., Nusrat, A. and Parkos, C. A. ( 2006 ). Microtubules...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (19): 4375–4380.
Published: 1 October 2005
...Ina Weisswange; Till Bretschneider; Kurt I. Anderson Actin polymerization drives many cellular events, including endocytosis, pathogen rocketing, and cell spreading. Force generation and polymerization regulation are intimately linked where an actin meshwork attaches to, and pushes against...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (1): 79–87.
Published: 1 January 2005
... with increased invasiveness. Cortactin can regulate actin dynamics directly via its N-terminal half, which can bind and activate the Arp2/3 complex. The C-terminal portion of cortactin, however, is thought to have limited function in its regulation of the actin polymerization machinery. In this report, we...
Journal Articles
In collection:
Lipid biology
J Cell Sci (2004) 117 (17): 3923–3933.
Published: 1 August 2004
... cluster, tyrosine-phosphorylated proteins accumulate, and intense actin polymerization occurs. We show that actin polymerization is controlled by the small GTPases Cdc42 and Rac, which become activated upon infection. Expression of dominant negative forms of these GTPases inhibits C. caviae entry...
Journal Articles
J Cell Sci (2004) 117 (15): 3077–3086.
Published: 1 July 2004
... with N-WASP, a potent activator of the Arp2/3 complex that forms a critical part of the actin polymerization machinery. Syndapin oligomers can thereby couple bursts of actin polymerization with the vesicle fission step involving dynamins. This allows newly formed vesicles to move away from the donor...
Journal Articles
J Cell Sci (2004) 117 (15): 3367–3377.
Published: 1 July 2004
... of Geneva, 1211 Geneva 4, Switzerland ‡ Present address: Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK 23 2 2004 © The Company of Biologists Limited 2004 2004 Actin Nemaline myopathy Actin polymerization Protein folding...
Journal Articles
J Cell Sci (2003) 116 (12): 2389–2397.
Published: 15 June 2003
.... * Author for correspondence (e-mail: kdemali@med.unc.edu ) © The Company of Biologists Limited 2003 2003 Adhesion Protrusion Actin polymerization Phagocytosis Extension of the cell surface is an early step in several cellular processes, including cell migration, neurite outgrowth...