.... WASH Wash regulatory complex Nuclear envelope budding Nuclear exit Arp2/3 Actin nucleation Vesicle-mediated nucleocytoplasmic transport National Institutes of Health 10.13039/100000002 R01 AG023779 National Cancer Institute 10.13039/100000054 P30 CA015704...

.../ Highlighted Article: The vesicle-tethering and fusion factors Boi1 and Boi2 are shown to initiate the formation of actin filaments by recruiting the Bni1–Bud6 actin nucleation complex to sites of exocytosis. Polar growth Vesicular traffic Actin nucleation Cdc42 Split-Ubiquitin Yeast...

... cell membranes for motility, differentiation or cell division, the actin cytoskeleton provides forces to shape and move intracellular membranes of organelles and vesicles. To establish the many different actin assembly functions required in time and space, actin nucleators are targeted to specific...

... and unpolymerizable actin mutants activate mDia1 to initiate fast directional movement. The FH2 region, the core domain for actin nucleation, is sufficient to respond to latrunculin B (LatB) to increase its actin nucleation frequency. Simulation analysis revealed an unexpected paradoxical effect of LatB that leads...

.... Our data suggest that binding of the Arp2/3 complex is mediated by specific interactions dependent on arginine residues within the 146-KKRRK-150 motif present in ActA. Actin nucleation Scar WASP ActA Listeria monocytogenes Listeria monocytogenes is a gram positive facultative...

... for accumulation of F-actin at the leading edge and its relationship to lamellipod extension in response to EGF, we have studied the kinetics and location of EGF-induced actin nucleation activity in MTLn3 cells and characterized the actin dynamics at the leading edge by measuring the changes at the pointed...