1-20 of 27
Keywords: Acetylation
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2019) 132 (21): jcs232389.
Published: 01 November 2019
... GRASP55 (also known as GORASP2) in mitosis when GRASP55 is highly acetylated on K50. Expression of wild-type and the K50R acetylation-deficient mutant of GRASP55, but not the K50Q acetylation-mimetic mutant, in GRASP55 and GRASP65 (also known as GORASP1) double-knockout cells, rescued the Golgi structure...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (24): 4120–4131.
Published: 15 December 2017
... and microtubule-associated proteins. Acetylation of α-tubulin lysine 40 (K40) is a prominent and conserved modification of neuronal microtubules. However, the cellular role of microtubule acetylation remains controversial. To resolve how microtubule acetylation might affect neuronal morphogenesis, we mutated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2926–2940.
Published: 01 September 2017
... Chromatin Histone Acetylation Microscopy Author contributions Conceptualization: L.S., C.J., Z.A.K.; Methodology: L.S., Z.A.K.; Software: L.S.; Validation: L.S.; Formal analysis: L.S., A.L., S.K., L.B.; Investigation: L.S., S.K., L.R., W.E., T.J., H.V.; Resources: H.S., C.J., Z.A.K.; Writing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (23): 4411–4423.
Published: 01 December 2016
... in piericidin-A- and antimycin-A-treated cells) appeared not to be involved in the stimulation of glucose uptake. Treatment with mitochondrial inhibitors increased NAD + and NADH levels (associated with a lower NAD + :NADH ratio) but did not affect the level of Glut1 acetylation. Stimulation of glucose uptake...
Journal Articles
J Cell Sci (2016) 129 (13): 2501–2513.
Published: 01 July 2016
... that surrounds the human SAS6 cartwheel hub. Interestingly, depletion of CEP295 not only inhibits the recruitments of POC5 and POC1B to the distal half centrioles in G2, resulting in shorter centrioles, it also blocks the post-translational modification of centriolar microtubules (e.g. acetylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 417–429.
Published: 15 January 2016
... locus, induces large-scale chromatin decondensation, predominantly during G1 phase of the cell cycle. Orc5 associates with the H3 histone acetyl transferase GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5. In the absence of Orc5, histone H3 acetylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2430–2436.
Published: 15 July 2015
... as CREBBP), but reduces CBP-mediated acetylation and chromatin recruitment of RelA. Thus, β-catenin selectively regulates NF-κB gene expression through its negative effects on RelA acetylation. This anti-inflammatory effect may be relevant for cancer treatment. Total proteins were isolated using RIPA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 913–922.
Published: 01 March 2015
...-terminus and that residues surrounding the second NLS sequence are acetylated. Treatment of cells with deacetylase inhibitors or expression of active Rac1 promotes Net1A acetylation. Deacetylase inhibition is sufficient for Net1A relocalization outside the nucleus, and replacement of the N-terminal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4954–4963.
Published: 15 November 2014
... excessive production of mitochondrial reactive oxygen species and oxidative damage, a defect suppressed by an acetylation-resistant MFN1 mutant. In mice subjected to fasting, skeletal muscle mitochondria undergo dramatic fusion. Remarkably, fasting-induced mitochondrial fusion is abrogated in HDAC6-knockout...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3659–3665.
Published: 01 September 2014
... as EP300) in controlling stimulus-specific ubiquitylation of RelA, through modulation of COMMD1. We show that p300 is required for stress-mediated ubiquitylation and nucleolar translocation of RelA, but that this effect is indirect. We also demonstrate that COMMD1 is acetylated by p300 and that acetylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1441–1453.
Published: 01 April 2014
... cachexia. However, the mechanisms that lead to FoxO activation are not well defined. Recent data from our laboratory and others indicate that the activity of FoxO is repressed under basal conditions via reversible lysine acetylation, which becomes compromised during catabolic conditions. Therefore, we...
Journal Articles
J Cell Sci (2013) 126 (21): 4843–4849.
Published: 01 November 2013
... acetylation mediates cellular autophagy, we investigated whether mitochondrial acetylation modulates mitochondrial autophagy (mitophagy). Knockdown of GCN5L1, a component of the mitochondrial acetyltransferase machinery, diminished mitochondrial protein acetylation and augmented mitochondrial enrichment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1071–1080.
Published: 01 March 2013
... 2013. Published by The Company of Biologists Ltd 2013 Microtubule Macroautophagy Phagocytosis Phagophore Cell signaling Lysosome Acetylation Molecular motor Autophagy is a catabolic process that leads to the degradation of cytoplasmic components by lysosomes. There are several...
Journal Articles
J Cell Sci (2013) 126 (1): 31–41.
Published: 01 January 2013
... chromosome condensation. Little is known, however, regarding the mechanisms through which cohesin functions are directed. Recent findings reveal that Eco1-mediated acetylation of different lysine residues in Smc3 during S phase promote either cohesion or condensation. Phosphorylation and SUMOylation...
Journal Articles
J Cell Sci (2013) 126 (1): 149–162.
Published: 01 January 2013
...Tatiana Catarino; Luís Ribeiro; Sandra D. Santos; Ana Luísa Carvalho Summary Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition have not been addressed. We found that protein acetylation promotes the dendritic clustering of the excitatory postsynaptic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 892–899.
Published: 15 March 2011
... activation. pp32 was found to be associated with ISG promoters in IFN-untreated cells, and its binding amount fluctuated as a function of time after IFN treatment. short interfering RNA (siRNA)-mediated knockdown of pp32 expression reduced the histone acetylation level on ISG promoters, suggesting that pp32...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4251–4258.
Published: 15 December 2010
... is hyperacetylated at Lys310 in Sirt2 −/− cells after TNFα stimulation, which results in the increase in expression of a subset of p65 acetylation-dependent target genes. Our work provides evidence that p65 is deacetylated by SIRT2 in the cytoplasm to regulate the expression of specific NF-κB-dependent genes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (21): 3718–3726.
Published: 01 November 2010
...Adam Pickard; Ping-Pui Wong; Dennis J. McCance Although the retinoblastoma protein (Rb) functions as a checkpoint in the cell cycle, it also regulates differentiation. It has recently been shown that Rb is acetylated during differentiation; however, the role of this modification has not been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (19): 3235–3243.
Published: 01 October 2010
...Arthur T. Coulton; Daniel A. East; Agnieszka Galinska-Rakoczy; William Lehman; Daniel P. Mulvihill Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal methionine...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (19): 3531–3541.
Published: 01 October 2009
... with the class I and II histone deacetylase inhibitor TSA, as well as the selective HDAC6 inhibitor tubacin, increased microtubule acetylation and significantly reduced velocities of microtubule growth and shrinkage. siRNA-mediated knockdown of HDAC6 also increased microtubule acetylation but, surprisingly, had...
Includes: Multimedia, Supplementary data