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Keywords: ARF6
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (2): jcs249565.
Published: 22 January 2021
...-ciliary vesicles at the distal appendages of the mother centriole through mechanisms that remain unclear. Here, we report that EFA6A (also known as PSD), an exchange factor for the small G protein Arf6, is involved in early stage of ciliogenesis by promoting the fusion of distal appendage vesicles forming...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs213314.
Published: 25 June 2018
... (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins. Here, we report that these sphingolipids disrupt endocytic recycling by inactivating the small GTPase ARF6. Consistent with reported roles for ARF6 in maintaining the tubular...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2018) 131 (11): jcs216598.
Published: 11 June 2018
... that the GTPase ARF6 prevents the premature loss of sister chromatid cohesion. During mitosis, ARF6-depleted cells normally completed chromosome congression. However, at the metaphase plate, chromosomes failed to establish stable kinetochore-microtubule attachments because of the impaired cohesion at centromeres...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2405–2415.
Published: 15 July 2017
... the ability of T cells to form a cell–cell conjugate with antigen-presenting cells (APCs). We show that CIE occurs in both the Jurkat T cell line and primary human T cells. In Jurkat cells, the activities of two guanine nucleotide binding proteins, Arf6 and Rab22 (also known as Rab22a), influence CIE...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4913–4925.
Published: 01 November 2013
... in the presence or absence of inhibitors that established their differential dependence on specific endocytic adaptor proteins. The topology of antigen-bound FcεRI, clathrin, dynamin, Arf6 and Eps15-positive structures were analyzed by 2D and 3D immunoelectron microscopy techniques, revealing their remarkable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2424–2435.
Published: 01 June 2013
.../ACAP2 and recruits them to perinuclear Arf6-positive endosomes in response to nerve growth factor stimulation. MICAL-L1 and centaurin-β2 then cooperatively recruit EHD1 to the same compartment by functioning as a scaffold for EHD1 and as an inactivator of Arf6, respectively. We propose that Rab35...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2235–2243.
Published: 01 May 2012
...Hotaka Kobayashi; Mitsunori Fukuda Two small GTPases, Rab and Arf, are well-known molecular switches that function in diverse membrane-trafficking routes in a coordinated manner; however, very little is known about the direct crosstalk between Rab and Arf. Although Rab35 and Arf6 were independently...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1129–1140.
Published: 01 March 2012
... of syntenin with syndecan heparan sulphate proteoglycans, which act as co-receptors for adhesion molecules and growth factors. Furthermore, we show that the interaction of syntenin with phosphatidylinositol 4,5-bisphosphate (PIP2) and with the small GTPase ADP-ribosylation factor 6 (Arf6), which regulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4062–4069.
Published: 15 November 2009
... with cargo that traffic in the Arf6 pathway and in large vacuoles in cells expressing the Arf6 dominant-active mutant. These results show that PrP c is internalized in a clathrin-independent pathway that is associated with Arf6. * Author for correspondence ( greenel@helix.nih.gov ) 24 8 2009...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2127–2136.
Published: 15 June 2009
... cell spreading. Moreover, in Rac3-expressing cells, Arf6 activity is strongly reduced and the Arf6-GAP activity of GIT1 is required for Rac3 downstream signaling. Indeed, expression of wild-type Arf6 or the Arf6-GEF ARNO induced cell spreading in the otherwise rounded Rac3-expressing cells. Our data...
Journal Articles
J Cell Sci (2008) 121 (24): 4008–4017.
Published: 15 December 2008
...Alan W. Lau; Margaret M. Chou The ADP-ribosylation factor 6 (Arf6) GTPase functions as a key regulator of endocytic trafficking, participating in clathrin-independent endocytosis in most cell types. Unexpectedly, we found that siRNA-mediated depletion of clathrin or of adaptor protein 2 (AP-2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3155–3166.
Published: 01 October 2008
... not require Rho-family GTPase activity. Accumulation of ErbB2 in vesicles containing constitutively active Arf6-Q67L occurred only without GA treatment; Arf6-Q67L did not slow transport to lysosomes in GA-treated cells. Further characterization of this novel clathrin-, caveolae- and Rho-family-independent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (15): 2489–2497.
Published: 01 August 2007
... of the calcium-sensing receptor (CaSR), a GPCR that promotes chemotaxis by detecting increases in extracellular calcium, triggers plasma membrane (PM) ruffling via a pathway that involves β-arrestin 1, Arf nucleotide binding site opener (ARNO), ADP-ribosylating factor 6 (ARF6) and engulfment and cell motility...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 792–801.
Published: 01 March 2007
... characterisation of centaurin-α 2 , which is structurally related to the centaurin-α 1 ARF6 GAP. centaurin-α 2 contains an N-terminal GAP domain followed by two pleckstrin homology (PH) domains (N-PH and C-PH). In vitro, GFP-centaurin-α 2 specifically binds the phosphatidylinositol (PI) 3-kinase lipid products, PI...
Journal Articles
J Cell Sci (2006) 119 (23): 4866–4877.
Published: 01 December 2006
... mutants or depletion of Rab8 by RNA interference inhibit protrusion formation, but promote cell-cell adhesion and actin stress fiber formation, whereas expression of the constitutively active Rab8-Q67L has the opposite effect. Rab8 localization overlaps with both Rab11 and Arf6, and is functionally linked...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (11): 2471–2484.
Published: 01 June 2005
... site, failed to colocalize with KIF13B in vivo. Finally, we demonstrate that KIF13B binding suppresses the ARF6 GAP activity of centaurin-α 1 in intact cells. Together, our data suggest a mechanism where direct binding between centaurin-α 1 and KIF13B could concentrate centaurin-α 1 at the leading...
Journal Articles
J Cell Sci (2004) 117 (16): 3473–3480.
Published: 15 July 2004
... at sites of bacterial adhesion. Induction of PtdIns(4,5) P 2 -enriched ruffles and PtdIns(4,5) P 2 -positive, actin-coated vacuoles by Arf6-mediated activation of PtdIns4 P 5-kinase also leads to a concomitant accumulation of the annexin 2-p11 complex and the PH domain. Binding studies with immobilized...
Journal Articles
J Cell Sci (2004) 117 (11): 2389–2398.
Published: 01 May 2004
...Eric Macia; Frédéric Luton; Mariagrazia Partisani; Jacqueline Cherfils; Pierre Chardin; Michel Franco The function of Arf6 has been investigated largely by using the T27N and the Q67L mutants, which are thought to be blocked in GDP- and GTP-bound states, respectively. However, these mutants have...