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Keywords: APP endocytosisClose
In collection:Cell Biology and Disease
Tatiana Burrinha, Isak Martinsson, Ricardo Gomes, Ana Paula Terrasso, Gunnar K. Gouras, Cláudia Guimas Almeida
Journal: Journal of Cell Science
J Cell Sci (2021) 134 (9): jcs255752.
Published: 17 May 2021
... is known about the underlying cell biological mechanisms. We studied neuronal aging using normal-aged brain and aged mouse primary neurons that accumulate lysosomal lipofuscin and show synapse loss. We identified the upregulation of amyloid precursor protein (APP) endocytosis as a neuronal aging mechanism...
Includes: Supplementary data