...Stephanie Wales Tobin; Dabo Yang; John Girgis; Ali Farahzad; Alexandre Blais; John C. McDermott ABSTRACT Mycocyte enhancer factor 2 (MEF2) and activator protein 1 (AP-1) transcription complexes have been individually implicated in myogenesis, but their genetic interaction has not previously been...

... expression profiles, impaired the TCR-induced Ca 2+ flux and nuclear expression of NFAT2, suppressed upregulation of molecules essential for activation, and attenuated signalling pathways upstream of the AP-1 and NFκB complexes, leading to reduced activation of these important transcription factors...

...Jennifer Baltes; Jakob Vejby Larsen; Karthikeyan Radhakrishnan; Constanze Geumann; Manuel Kratzke; Claus Munck Petersen; Peter Schu ABSTRACT Here, we describe altered sorting of sortilin in adipocytes deficient for the σ1B-containing AP-1 complex, leading to the inhibition of adipogenesis. The AP-1...

... and that the skeleton is an endocrine organ. Therefore, modulating the activity of AP-1 transcription factors in osteoblasts might provide means for targeted therapies against metabolic diseases. Our data suggest that Adipoq is a molecule linking bone physiology to systemic metabolism in an endocrine fashion, much...

... of clathrin adaptor AP-1 complex, a negative regulator of Notch signalling. Together, our results further demonstrate the essential function of intracellular trafficking in regulating Notch-signalling-dependent binary cell fate acquisition and constitute an additional step toward the elucidation of the routes...

...Satoshi Kametaka; Ai Kametaka; Shinichi Yonekura; Mineyuki Haruta; Seiichi Takenoshita; Satoshi Goto; Satoshi Waguri Clathrin adaptor protein complex-1 (AP-1) and its accessory proteins play a role in the sorting of integral membrane proteins at the trans -Golgi network and endosomes...

.... ( 2000 ). Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass . Cell 100 , 197 - 207 . Eferl R. , Wagner E. F. ( 2003 ). AP-1: a double-edged sword in tumorigenesis . Nat. Rev. Cancer 3 , 859 - 868 . Eferl R. , Hoebertz...

...) within these cells. PKC is a potent inhibitor of the steroidogenic enzyme CYP17. We have demonstrated that, in the ovary, PKC activates expression of FOS, a member of the AP-1 family, and increased expression of this gene is linked to CYP17 downregulation. However, the pathway and the molecular mechanism...

... recognizes the cytoplasmic acidic-cluster-dileucine (ACLL) sorting signal of Lerp (lysosomal enzyme receptor protein), a homolog of mammalian mannose 6-phosphate receptors. Moreover, both dGGA and another type of TGN-localized clathrin adaptor, AP-1 (adaptor protein-1 complex), are shown to be involved...

... liposome tubulation in vitro and had a binding preference for PtdIns(4,5) P 2 . However, contrary to SNX9, which primarily acts in clathrin-mediated endocytosis at the plasma membrane, endogenous SNX18 localized to AP-1- and PACS1-positive endosomal structures, which were devoid of clathrin and resistant...

... ), and changes in the activity of the ZO-2-interacting transcription factor AP-1 have been associated with many cancers. Hence, it is likely that the junction-associated signalling pathways discussed here are deregulated in cancer cells. The reason for the difference in the functional consequences of ZO-1...

... of some integral membrane proteins from the trans-Golgi network to the vacuole lumen. AP-1 is a heterotetrameric clathrin adaptor protein complex that binds cargo proteins and clathrin coats, and regulates bi-directional protein trafficking between the trans-Golgi network and the endocytic/secretory...

... of a dominant-negative mutant of ARF1 induces BFA-like modifications in vimentin morphology. The BFA-dependent changes in vimentin architecture occurred concurrently with the release of the ARF1-regulated adaptor complexes AP-3 and AP-1 from membranes and adaptor redistribution to vimentin networks...

...Lore Florin; Nicole Maas-Szabowski; Sabine Werner; Axel Szabowski; Peter Angel In skin, fibroblasts of the connective tissue play a decisive role in epidermal homeostasis and repair by contributing to the regulation of keratinocyte proliferation and differentiation. The AP-1 transcription factor...

...Jochen Hess; Peter Angel; Marina Schorpp-Kistner The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It mediates gene regulation in response to a plethora of physiological and pathological stimuli, including cytokines, growth factors, stress signals, bacterial...

...Emmanuel Vial; Christopher J. Marshall The AP-1 (activator protein-1) complex, which consists of proteins of the Fos and Jun families, is thought to play an important role in the balance between cell proliferation and apoptosis, the response to genotoxic stress and cell transformation. In cells...

...Jochen Hess; Bettina Hartenstein; Sibylle Teurich; Dirk Schmidt; Marina Schorpp-Kistner; Peter Angel Functional analysis in mice has established an absolute requirement of JunB, a member of the AP-1 transcription factor family, during early embryonic development. To investigate the role of JunB...

... clathrin adaptor complex AP-1 has long been thought to mediate anterograde transport from the TGN to endosomes. However, recent studies of AP-1-knockout mice implicate AP-1 in retrograde as well as anterograde transport. The recently identified Golgi-associated,γ-ear-containg, ARF-binding (GGA) proteins...

...,mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 93 , 9437 -9442. Karin, M. ( 1996 ). The regulation of AP-1 activity by mitogen-activated protein kinases. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351 , 127 -134. Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z. and Leder...

... of MPR300 in μ1A-adaptin-deficient fibroblasts, which lack a functional AP-1 clathrin adaptor complex. In μ1A-adaptin-deficient fibroblasts, the homologous MPR46 accumulates in endosomes due to a block in retrograde transport to the trans-Golgi network. The MPR300-mediated endocytosis is markedly enhanced...