...Jordana B. Freemantle; Mhairi C. Towler; Emma R. Hudson; Thomas Macartney; Monika Zwirek; David J. K. Liu; David A. Pan; Sreenivasan Ponnambalam; D. Grahame Hardie ABSTRACT AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular functions in response to changes in energy...

... permeability, signal transduction and the role of AMP-activated protein kinase (AMPK). Following stimulation with either vascular endothelial growth factor (VEGF-A) or bradykinin (BK), AMPK was rapidly and strongly phosphorylated and acted as a key mediator of permeability downstream of Ca 2+ . Accordingly...

...D. Grahame Hardie The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that inhibits ATP production or increases ATP consumption, this is amplified by adenylate kinase into a much larger increase...

... to involve AMP-activated protein kinase: in the current study, osmotic and metabolic stresses were found to result in activation of the α1 isoform of AMP-activated protein kinase, and transport stimulation could be mimicked both by 5-aminoimidazole-4-carboxamide ribonucleoside and by infection of cells...