... to as alternative lengthening of telomeres (ALT). How ALT cells resolve replication stress to support their growth remains incompletely characterized. Here, we report that CSB (also known as ERCC6) promotes recruitment of HR repair proteins (MRN, BRCA1, BLM and RPA32) and POLD3 to ALT telomeres, a process...

...Florence R. Wilson; Angus Ho; John R. Walker; Xu-Dong Zhu ABSTRACT TRF1, a duplex telomeric DNA binding protein, is implicated in homologous-recombination-based alternative lengthening of telomeres, known as ALT. However, how TRF1 promotes ALT activity has yet to be fully characterized. Here we...

...Sarah Osterwald; Katharina I. Deeg; Inn Chung; Daniel Parisotto; Stefan Wörz; Karl Rohr; Holger Erfle; Karsten Rippe ABSTRACT The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape senescence and apoptosis in the absence of active telomerase. A characteristic feature...

... complexes and chimeric mTERT-hTERT-hTR complexes in vitro and in immortalized human alternative lengthening of telomere (ALT) cells. Our data suggest that species-specific determinants of activity, processivity and telomere function map not only to the TR but also to the TERT component. The presence...

... of Biologists Limited 2009 2009 Telomeres Telomerase Shelterin ALT Aging Recombination Genome stability Telomeres consist of a repetitive non-coding sequence that terminates in a single-stranded overhang at the end of linear chromosomes in eukaryotes and some prokaryotes. Both the overhang...