[email protected] ) Competing interests The authors declare no competing or financial interests. 10 09 2014 16 01 2015 © 2015. Published by The Company of Biologists Ltd 2015 ADAM Development Neural crest Wnt Xenopus laevis The cranial neural crest (CNC) is a stem cell...

..., little is known about dispersion of this ligand from cancer cells. Using co-culture models in conjunction with a newly developed reporter system, we were able to show that different members of the ADAM family of metalloproteinases strongly contribute to the release of endogenous bioactive Hh from...

... receptor cleavage and concomitantly enhanced receptor shedding by metalloproteases of the ADAM family. Receptor degradation and shedding are thus interconnected phenomena with a single protein, RNF41, determining the balance. Fig. 1. Identification of RNF41 as a LR-complex-interacting protein...

... to intestinal epithelial cell homeostasis. * Author for correspondence (e-mail: [email protected] ) 10 4 2007 © The Company of Biologists Limited 2007 2007 Bacteroides fragilis Bacteroides fragilis toxin Metalloproteases E-cadherin ADAM γ-secretase Bacteroides fragilis...

...Guo-Zhang Zhu; Diana G. Myles; Paul Primakoff ABSTRACT Plasma membrane-anchored proteases have key roles in cell signaling, migration and refashioning the cell surface and its surroundings. We report the first example of a plasma membrane-anchored protease on mature sperm, testase 1 ( ADAM 24...

... that ectodomain shedding is a highly regulated process that can be stimulated by EGFR signalling pathways and integrin ligation. * Author for correspondence ( e-mail: [email protected] ) © 2001 by Company of Biologists 2001 Ectodomain shedding Epidermal growth factor receptor ADAM TIMP...

...Deepa Nath; Patrick M. Slocombe; Ailsa Webster; Paul E. Stephens; Andrew J. P. Docherty; Gillian Murphy ABSTRACT The ADAMs (A D isintegrin and M etalloprotease Domains) are a family of membrane-anchored proteins that play a role in fertilisation, myoblast fusion and ectodomain shedding of cell...

... be critically involved in intracellular signalling events. * Author for correspondence (e-mail: [email protected] ) © 2000 by Company of Biologists 2000 Amyloid precursor protein Secretase BACE Fe65 Presenilin ADAM In the past two years enormous progress has been...

...Johannes Schlöndorff; Carl P. Blobel ABSTRACT Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the ectodomains of proteins such as tumor necrosis factor α (TNFα), and because of their roles in Notch-mediated signaling...