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Keywords: 53BP1
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Journal Articles
In collection:
Cell Cycle
J Cell Sci (2023) 136 (1): jcs260027.
Published: 6 January 2023
...Marina Bleiler; Aiyana Cyr; Dennis L. Wright; Charles Giardina ABSTRACT 53BP1 (also known as TP53BP1) is a key mediator of the non-homologous end joining (NHEJ) DNA repair pathway, which is the primary repair pathway in interphase cells. However, the mitotic functions of 53BP1 are less well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259009.
Published: 19 July 2022
... constrained by concerns of unequal nuclear expansion. Here, we demonstrate the conditions for isotropic expansion of the nucleus at a resolution equal to or better than 120–130 nm (pre-expansion). Using the DNA damage response proteins BRCA1, 53BP1 (also known as TP53BP1) and RAD51 as exemplars, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259207.
Published: 19 April 2022
... NAD + -dependent deacetylase Sirtuin 7 in vitro . As assessed by their inhibition of rDNA transcription, pre-rRNA processing and formation of etoposide-induced 53BP1 foci, menadione and plumbagin also inhibited Sirtuin 7 catalytic activity in vivo . Second, we established that when sulfhydryl...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3347–3359.
Published: 1 October 2017
... joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2306–2316.
Published: 15 July 2017
...Vincent Duheron; Nadine Nilles; Sylvia Pecenko; Valérie Martinelli; Birthe Fahrenkrog ABSTRACT The nuclear basket of nuclear pore complexes (NPCs) is composed of three nucleoporins: Nup153, Nup50 and Tpr. Nup153 has a role in DNA double-strand break (DSB) repair by promoting nuclear import of 53BP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 147–157.
Published: 1 January 2014
... ZMPSTE24, whereas other nuclear envelope constituents are mostly unaffected and cells do not enter senescence. Accumulation of prelamin A in nuclei of cells from centenarians elicits loss of heterochromatin, as well as recruitment of the inactive form of 53BP1, associated with rapid response to oxidative...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3529–3534.
Published: 1 August 2012
... on damaged chromatin actually relates to DNA repair remains unclear. Here, we use super-resolution microscopy to examine the spatial distribution of BRCA1 and 53BP1 proteins within single IRIF at subdiffraction-limit resolution, yielding an unprecedented increase in detail that was not previously apparent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2509–2522.
Published: 15 May 2012
... of the helicase. 53BP1 Bloom helicase Nuclear localization signal Tom20 receptor Mitochondrial localization signal References Achanta   G. , Sasaki   R. , Feng   L. , Carew   J. S. , Lu   W. , Pelicano   H. , Keating   M. J. , Huang   P. ( 2005 ). Novel role of p53...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (9): 2043–2055.
Published: 1 May 2005
...Fiona Pryde; Shirin Khalili; Kathryn Robertson; Jim Selfridge; Ann-Marie Ritchie; David W. Melton; Denis Jullien; Yasuhisa Adachi 53BP1 protein is re-localized to the sites of DNA damage after ionizing radiation (IR) and is involved in DNA-damage-checkpoint signal transduction. We examined...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (8): 1629–1639.
Published: 15 April 2005
... but not for BRCA1 or H2AX phosphorylation following DNA damage. Expression levels of BRCT mediator/adaptor proteins MDC1 and 53BP1, which are required for ATM-mediated pathways, are reduced in cells lacking STAT-1. Enforced expression of MDC1 into STAT-1-deficient cells restored ATM-mediated phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2002) 115 (1): 71–79.
Published: 1 January 2002
...Denis Jullien; Paola Vagnarelli; William C. Earnshaw; Yasuhisa Adachi 53BP1 is a vertebrate BRCT motif protein, originally described as a direct interactor of p53, which has recently been shown to be implicated in the early response to DNA damage. Upon DNA damage, 53BP1 re-localises to discrete...