1-18 of 18
Keywords: 14-3-3
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2014) 127 (9): 2106–2119.
Published: 01 May 2014
... channels and receptors present retrieval motifs to COPI vesicle coats and are retained in the early secretory pathway. In some cases, the interaction with COPI is prevented by binding to 14-3-3 proteins. However, the functional significance of this antagonism between COPI and 14-3-3 in terminally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 137–146.
Published: 01 January 2014
... ). Fluid and solute transport in bone: flow-induced mechanotransduction.   Annu. Rev. Fluid Mech.   41 , 347 – 374 . 10.1146/annurev.fluid.010908.165136 Gardino   A. K. , Smerdon   S. J. , Yaffe   M. B. ( 2006 ). Structural determinants of 14-3-3 binding specificities and regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4173–4186.
Published: 15 September 2013
... recognized as an important step in the aggresome formation process, the molecular machinery that mediates the association of cargos with the dynein motor is poorly understood. Here, we report a new aggresome-targeting pathway that involves isoforms of 14-3-3, a family of conserved regulatory proteins. 14-3-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2014–2026.
Published: 01 May 2013
... quantitative proteomics and biochemistry, that 14-3-3 proteins bind to phosphorylated TRIM32 and prevent TRIM32 autoubiquitylation and the formation of TRIM32-containing cytoplasmic bodies, which are potential autoregulatory mechanisms that can reduce the concentration of soluble free TRIM32. The 14-3-3–TRIM32...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 427–436.
Published: 15 January 2013
... in axon degeneration of motor and sensory neurons, which are thought to be the cause of CMT disease type 2E. In the present study, we investigated the dynamic regulation of NF-L assembly and the mechanism of aggregate formation of CMT NF-L mutants. We report that 14-3-3 proteins interact with NF-L...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5887–5896.
Published: 01 December 2012
... kinase activation and BIN1 recruitment to determine EGFR fate. * Author for correspondence ( colicelli@mednet.ucla.edu ) 1 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Endocytosis EGFR RIN1 RAB5 ABL BIN1 14-3-3 Epidermal growth factor receptor (EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1716–1726.
Published: 01 April 2012
...David Aristizábal-Corrales; Laura Fontrodona; Montserrat Porta-de-la-Riva; Angel Guerra-Moreno; Julián Cerón; Simo Schwartz, Jr 14-3-3 proteins have been extensively studied in organisms ranging from yeast to mammals and are associated with multiple roles, including fundamental processes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2165–2174.
Published: 01 July 2011
... of these effectors from immune response cells. Here, we report that Drosophila 14-3-3 ε mutants exhibit reduced survival when infected with either Gram-positive or Gram-negative bacteria, indicating a functional role for 14-3-3ε in innate immunity. In 14-3-3 ε mutants, there was a reduced release of the anti...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 57–67.
Published: 01 January 2011
... translocates to the P-body, where mRNA degradation, translational repression and mRNA surveillance take place. Depletion of Lats2 or 14-3-3γ by siRNA inhibits P-body formation in response to UV, newly implicating Lats2 and 14-3-3 as regulators of P-body formation. By contrast, siRNA-mediated depletion of Lats1...
Journal Articles
J Cell Sci (2009) 122 (24): 4419–4426.
Published: 15 December 2009
... in the initiation of DNA replication. Here, we present evidence that 14-3-3 proteins are novel regulators of the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae . The results show that the Bmh2 protein, one of the two 14-3-3 homologues in S. cerevisiae , interacts with Mcm2 and Orc2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1654–1664.
Published: 15 May 2009
... et al., 2003 ). This analysis identified a putative mode II 14-3-3-binding motif, RX(ϕ)XS( P )XP (where ϕ designates an aromatic residue, and S( P ) is phosphoserine), located between residues R974 and L980 ( Fig. 1E ). Like the paxillin-binding sequence, this motif is conserved in α4 between species...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (19): 4059–4070.
Published: 01 October 2006
...Olga Göransson; Maria Deak; Stephan Wullschleger; Nick A. Morrice; Alan R. Prescott; Dario R. Alessi Members of the PAR-1/MARK kinase family play critical roles in polarity and cell cycle control and are regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3695–3704.
Published: 01 September 2006
... the signal. We now show that 14-3-3 proteins regulate the NFκB signaling pathway by physically interacting with p65 and IκBα proteins. We identify two functional 14-3-3 binding domains in the p65 protein involving residues 38-44 and 278-283, and map the interaction region of IκBα in residues 60-65. Mutation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (9): 1923–1934.
Published: 01 May 2005
... such as the regulation of voltage-gated calcium channel activity and remodeling of cell shape. The GTPase Kir/Gem inhibits the activity of calcium channels by interacting with the β-subunit and also regulates cytoskeleton dynamics by inhibiting the Rho-Rho kinase pathway. In addition, Kir/Gem interacts with 14-3-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (10): 1875–1884.
Published: 15 April 2004
...Michele K. Dougherty; Deborah K. Morrison One of the most striking `rags to riches' stories in the protein world is that of 14-3-3, originally identified in 1967 as merely an abundant brain protein. The first clues that 14-3-3 would play an important role in cell biology came almost 25 years later...
Journal Articles
J Cell Sci (2002) 115 (21): 4133–4148.
Published: 01 November 2002
... correlation to alterations in the actin- and tubulin-based systems. Interestingly, the short-lived and rather small orthovanadate-induced cytokeratin granules contained the cytoskeletal crosslinker plectin but lacked the cytokeratin-solubilising 14-3-3 proteins. By contrast, the long-lived and larger...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (17): 3479–3490.
Published: 01 September 2002
... as a protein kinase, but is a very good substrate for protein kinase A (PKA),which phosphorylates a total of four sites in the N-terminus of PCTAIRE-1. Phosphorylation of one of these sites, Ser119, generates a 14-3-3 binding site, which is functional in vitro as well as in vivo. Mutation of another PKA site...
Journal Articles
J Cell Sci (2001) 114 (19): 3445–3454.
Published: 01 October 2001
...Tin Tin Su; Devin H. Parry; Bryon Donahoe; Cheng-Ting Chien; Patrick H. O’Farrell; Amanda Purdy Drosophila 14-3-3ε and 14-3-3ζ proteins have been shown to function in RAS/MAP kinase pathways that influence the differentiation of the adult eye and the embryo. Because 14-3-3 proteins have a conserved...