... , M. ( 2023 ). Partial closure of the γ-tubulin ring complex by CDK5RAP2 activates microtubule nucleation . Dev. Cell 59 , 3161 - 3174 . 10.1016/j.devcel.2024.09.002 . Yang , R. and Feldman , J. L. ( 2015 ). SPD-2/CEP192 and CDK are limiting for microtubule-organizing...

...) that contain γ-tubulin, and GCPs 2 and 3; and γ-tubulin ring complexes (γTuRCs) that contain multiple γTuSCs in addition to GCPs 4, 5 and 6. Whereas the structure and assembly properties of γTuSCs have been intensively studied, little is known about the assembly of γTuRCs and the specific roles of GCPs 4, 5...

... understood. γ-tubulin has been found in complexes of various sizes but several lines of evidence suggest that only large, ring-shaped complexes function as efficient microtubule nucleators. Human γ-tubulin ring complexes (γTuRCs) are composed of γ-tubulin and the γ-tubulin complex components (GCPs) 2, 3, 4...

...Ramona Bahtz; Joerg Seidler; Marc Arnold; Uta Haselmann-Weiss; Claude Antony; Wolf D. Lehmann; Ingrid Hoffmann Centriole duplication occurs once per cell cycle and requires Plk4, a member of the Polo-like kinase family. A key component of the centrosome is the γ-tubulin ring complex (γ-TuRC...