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Keywords: γ-tubulin
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2024) 137 (9): jcs261512.
Published: 10 May 2024
...-specific morphology, which relies on dynamic support by microtubules (MTs). An important player is the augmin complex (hereafter augmin), which binds to existing MT filaments and recruits the γ-tubulin ring complex (γ-TuRC), to form branched MTs. In cultured neurons, augmin is important for neurite...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (2): 406–419.
Published: 15 January 2017
...Rosa Ramírez Cota; Neus Teixidó-Travesa; Artur Ezquerra; Susana Eibes; Cristina Lacasa; Joan Roig; Jens Lüders ABSTRACT Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (18): 3125–3135.
Published: 15 September 2010
... mutant β-catenin, which mimics mutations found in cancer, results in extra non-microtubule nucleating structures that contain a subset of centrosome proteins including γ-tubulin and centrin, but not polo-like kinase 4 (Plk4), SAS-6 or pericentrin. A transcriptionally inactive form of β-catenin also gives...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (12): 2094–2102.
Published: 15 June 2010
...Diane Colello; Carlos G. Reverte; Rachel Ward; Christopher W. Jones; Valentin Magidson; Alexey Khodjakov; Susan E. LaFlamme Microtubules nucleated from γ-tubulin ring complexes located at the centrosome regulate the localization of organelles, promote vesicular transport and direct cell migration...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (8): 1284–1292.
Published: 15 April 2008
... contributed equally to this work 22 1 2008 © The Company of Biologists Limited 2008 2008 RNAi Centrosome Microtubule Kinetochore γ-tubulin During mitosis, the microtubule network reorganizes into a bipolar spindle that ensures proper chromosome segregation by aligning...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 578–589.
Published: 1 March 2008
... of the neuron-precursor-cell-expressed developmentally downregulated protein 1 (NEDD1) family of conserved proteins have recently been implicated in recruiting γ-tubulin and its associated proteins, which together make up the γ-tubulin ring complex (γTuRC), to the centrosome. Human NEDD1 and its Drosophila...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2819–2827.
Published: 15 August 2007
.... 12 6 2007 © The Company of Biologists Limited 2007 2007 Arabidopsis thaliana AtKRP125 Cortical microtubules Eg5 γ-tubulin Root morphology The mitotic spindle separates replicated chromosomes, a hallmark process for the eukaryotic cell. Early observations on the mitotic...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (20): 4143–4153.
Published: 15 October 2006
... proteins and proteins that bind along the length or stabilize the plus ends of microtubules. Recent work has improved our understanding of the molecular mechanisms of MT formation. In particular, it has shown that γ-tubulin and its associated proteins play key roles in microtubule nucleation and spindle...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (19): 4011–4019.
Published: 1 October 2003
... and CDCrel-1, a substrate of parkin. The recruitment of parkin was apparently mediated through its binding to γ-tubulin, which has been shown to accumulate in the centrosome in response to misfolded proteins. Furthermore, the effect was abrogated by the microtubule-depolymerizing drug colchicine...
Journal Articles
J Cell Sci (2003) 116 (5): 919–928.
Published: 1 March 2003
... The Company of Biologists Limited 2003 2003 Centriolar satellites PCM-1 Centrosome Pericentrin γ-Tubulin Centriolar satellites were initially identified by ultrathin section electron microscopy as electron-dense spherical granules ∼70-100 nm in diameter and localized around the centrosomes...
Journal Articles
J Cell Sci (2002) 115 (7): 1345–1354.
Published: 1 April 2002
.... (e-mail: [email protected] ) © The Company of Biologists Limited 2002 2002 Microtubule-associated protein Microtubule-organizing centre Katanin MOR1 Centrosome γ-Tubulin Plant cell For over a billion years, plants, animals, fungi and protists have been acquiring unique...
Journal Articles
J Cell Sci (2002) 115 (7): 1403–1410.
Published: 1 April 2002
... for the formation of spindles in mitosis and sperm meiosis. However, this phosphatase was apparently dispensable for female meiotic divisions, which do not depend on centrosomes. In the cell depleted of pph-4.1 activity,localization of γ-tubulin and a Polo-like kinase homologue to the centrosome was severely...
Journal Articles
J Cell Sci (2002) 115 (5): 1083–1092.
Published: 1 March 2002
...-specific antibody prevented the redistribution of γ-tubulin from the centrosome to the spindle in prometaphase CV-1 cells as assayed by immunofluorescence microscopy. Becauseγ-tubulin complexes can bind to pre-existing microtubule minus ends,these results could be explained by a model in which the broad...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (2): 413–422.
Published: 15 January 2001
...Yuki F. Inclán; Eva Nogales ABSTRACT αβ-tubulin heterodimers self-assemble to form microtubules nucleated by γ-tubulin in the cell. γ-tubulin is believed to recruit the αβ-tubulin dimers that form the minus ends of microtubules, but the molecular mechanism of this action remains a matter of heated...