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Keywords: β-arrestins
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Journal Articles
Chi Xu, Min-Hua Hong, Le-Sha Zhang, Yuan-Yuan Hou, Yu-Hua Wang, Fei-Fei Wang, Yue-Jun Chen, Xue-Jun Xu, Jie Chen, Xin Xie, Lan Ma, Zhi-Qiang Chi, Jing-Gen Liu
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (24): 4259–4270.
Published: 15 December 2010
... unclear. Here, we report that Ser363 in the δ-opioid receptor (δOR) determines the different abilities of the δOR agonists DPDPE and TIPP to activate ERK by G-protein- or β-arrestin-dependent pathways. Although both DPDPE and TIPP activated ERK1/2, they showed different temporal, spatial...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (2): 213–218.
Published: 15 January 2007
...Lan Ma; Gang Pei β-arrestin 1 and β-arrestin 2 are well-known negative regulators of G-protein-coupled receptor (GPCR) signaling. Upon GPCR activation, β-arrestins translocate to the cell membrane and bind to the agonist-occupied receptors. This uncouples these receptors from G proteins...