..., Albany, NY 12208-3479, USA. ‡ Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 17 03 2013 23 12 2013 © 2014. Published by The Company of Biologists Ltd 2014 α3β1 integrin Alternative splicing Breast...

... the molecular mechanism by which Gal-3 stimulates cell migration. We demonstrate here that exogenous Gal-3, but not Gal-1 or Gal-8, promotes cell scattering and formation of lamellipodia in human corneal epithelial cells in a β-lactose-inhibitable manner. α3β1 integrin was identified as the major Gal-3-binding...

... inhibitor. However, a CD151 mutant with impaired association with α3β1 integrin fails to restore junctional organization. These data reveal that, in addition to its roles in regulating tumor cell-substrate interactions, CD151 is also an important regulator of the stability of tumor cell-cell interactions...

... undetectable in MK –/– cells ( Fig. 3A , –/– lane) suggesting that α3β1 is required for MMP-9 mRNA expression. Indeed, restoration of α3β1 integrin expression in MK –/– cells through stable transfection with the human α3 subunit (see Fig. 3C ) restored MMP-9 mRNA expression ( Fig. 3A , –/–, α3 lane...

... (Cell Signaling Technology), 1:2000; goat anti-rabbit IgG (Pierce), 1:15,000; goat anti-mouse IgG (Pierce), 1:15,000. Chemiluminescence was performed using the SuperSignal Kit (Pierce). To determine whether α3β1 integrin plays a role in keratinocyte survival, we exploited keratinocyte cell...

... the α3β1 integrin in promoting the stabilization of leading lamellipodia in migrating keratinocytes. We demonstrate that this integrin is found at the leading edge of migrating keratinocytes and that inhibition of α3β1 binding to laminin-5 prevents the formation of stable leading lamellipodia. Consistent...