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Keywords: α-Ketoglutarate
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (17): 3317–3329.
Published: 1 September 2015
... under hypoxia. TRPC6 was rapidly activated by IGF-1R–PLCγ–IP 3 R pathway upon hypoxia. Inhibition of TRPC6 enhanced the levels of α-ketoglutarate and promoted hydroxylation of HIF-1α to suppress HIF-1α accumulation without affecting its transcription or translation. Dimethyloxalylglycine N...
Includes: Supplementary data