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Keywords: α-Catenin
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Journal Articles
J Cell Sci (2017) 130 (10): 1717–1729.
Published: 15 May 2017
...Leonid A. Serebryannyy; Alex Yemelyanov; Cara J. Gottardi; Primal de Lanerolle ABSTRACT α-Catenin is an F-actin-binding protein widely recognized for its role in cell–cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (24): 4496–4508.
Published: 15 December 2016
...Jaime Jurado; Joaquín de Navascués; Nicole Gorfinkiel ABSTRACT We have investigated how cell contractility and adhesion are functionally integrated during epithelial morphogenesis. To this end, we have analysed the role of α -Catenin , a key molecule linking E-Cadherin-based adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1150–1165.
Published: 15 March 2015
... to epithelial tissue stability and dynamic cell movements during development and tissue renewal. How this complex is regulated to accomplish these functions is not fully understood. We identified several phosphorylation sites in mammalian αE-catenin (also known as catenin α-1) and Drosophila α-Catenin within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 140–149.
Published: 01 January 2015
... strategies concomitantly suppressed the formation of nectin clusters. Furthermore, cadherin significantly increased the stability of nectin clusters, thereby making them resistant to the BC-12 antibody, which targets the nectin-2 adhesion interface. By testing different E-cadherin–α-catenin chimeras, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1779–1791.
Published: 15 April 2014
...Adrienne K. Barry; Hamid Tabdili; Ismaeel Muhamed; Jun Wu; Nitesh Shashikanth; Guillermo A. Gomez; Alpha S. Yap; Cara J. Gottardi; Johan de Rooij; Ning Wang; Deborah E. Leckband ABSTRACT The findings presented here demonstrate the role of α-catenin in cadherin-based adhesion and mechanotransduction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3904–3915.
Published: 01 September 2013
... upon neighboring epithelial cells binding to one another and forming adherens junctions, but the mechanism for how these processes are linked is poorly understood. Using a knockdown and substitution system, we studied whether ZO-1 binding to α-catenin is required for coupling tight junction assembly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 1058–1067.
Published: 15 February 2012
... complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a ‘hybrid adhering junction’ or ‘area composita’. The α-catenin family member αT-catenin, part of the N-cadherin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 233–245.
Published: 01 January 2012
...Ritu Sarpal; Milena Pellikka; Ridhdhi R. Patel; Felix Yan Wai Hui; Dorothea Godt; Ulrich Tepass α-catenin associates the cadherin–catenin complex with the actin cytoskeleton. α-catenin binds to β-catenin, which links it to the cadherin cytoplasmic tail, and F-actin, but also to a multitude of actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1357–1362.
Published: 01 May 2008
...Wen-Hui Lien; Olga Klezovitch; Manda Null; Valeri Vasioukhin β-catenin is a crucial mediator of the canonical Wnt-signaling pathway. α-catenin is a major β-catenin-binding protein, and overexpressed α-catenin can negatively regulate β-catenin activity. Thus, α-catenin may be an important modulator...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (22): 4599–4605.
Published: 15 November 2006
...Jeanie A. Scott; Alpha S. Yap To date, α-catenin has been best understood as an important cytoplasmic component of the classical cadherin complex responsible for cell-cell adhesion. By virtue of its capacity to bind F-actin, α-catenin was commonly envisaged to support cadherin function by coupling...
Journal Articles
J Cell Sci (2002) 115 (24): 4743–4753.
Published: 15 December 2002
..., a decreased affinity of the mutant protein to α-catenin was observed. Moreover, kinase assays in vitro demonstrate a CKII-dependent increase in the binding of wild-type β-catenin with α-catenin. In line with that, cells expressing Ser/Thr-mutant β-catenin exhibit an increased migratory potential, which...
Journal Articles
J Cell Sci (2001) 114 (12): 2265–2277.
Published: 15 June 2001
... in tight or septate junction formation. We show that DLG-1 colocalises with the junctional protein JAM-1 at CeAJs in a unit distinct from HMP-1/α-catenin, and apical to the laterally localised LET-413. Loss of dlg-1 activity leads to JAM-1 mislocalisation and the disappearance of the electron-dense...