Issues

Summary: Cell extrusion is a conserved process that leads to seamless expulsion of epithelial cells from tissues. This Cell Science at a Glance describes the functions and underlying mechanisms of cell extrusion.

Highlighted Article: A CRISPR screen in mESCs identifies signaling and transcriptional regulators of differentiation. Med12, a key hit, modulates gene expression and transitions between pluripotency states.

Summary: Structural and functional analyses of the binding between two nanobodies and the Cavin1 coiled-coil domain provide insights into cavin protein assemblies and caveola structures in cells.

Summary: The length but not the architecture of the α-solenoid domain within Vps41, a subunit of the vacuolar HOPS tethering and fusion complex, is essential for HOPS-mediated membrane fusion.

Summary: Cells move to areas of higher stiffness via a process called durotaxis. We show that pancreatic stellate cell durotaxis, which might be relevant in pancreatic cancer, is orchestrated by Piezo1, TRPV4 and TRPC1 channels.

Highlighted Article: Symmetry breakage at the cellular level requires positional information to direct cell extension or cell growth. We show that cell-end marker proteins fulfil this function and are crucial for hyphal turns to form ring-shaped traps.

Highlighted Article: EdU can be used to track the recruitment of leukocyte populations in sterile models of inflammation, including ischemic stroke and HCl aspiration.