Issues

Summary: A discussion of how mechanical and structural properties of the extracellular matrix regulate diverse motility mechanisms across 2D and 3D environments within development, tissue homeostasis, regenerative processes and disease.

Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to data analysis.

Highlighted Article: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

Summary: Phosphorylation of the fission yeast α-arrestin Aly3 at the C-terminus inhibits ubiquitylation of the hexose transporter Ght5 and is required for cell proliferation in low glucose.

Summary: Rab40 GTPases interact with AMBRA1 and cause its non-degradative ubiquitylation. AMBRA1 regulates cancer cell migration, and RNA sequencing reveals global gene profiles regulated by AMBRA1.

Highlighted Article: The disrupted cytoskeletal arrays within tendon cells in formin 3 mutants, along with the mid-filament localization of Formin 3, provide further insight into the specific actions of inverted formins.

Summary: Autosomal dominant DFNA11 deafness mutations in myosin-7A short circuit the normal autoregulation of the motor protein resulting in a form of the myosin that is constitutively active in cells.

Highlighted Article: Presentation of the first intracellular nanovesicle (INV) proteome, showing that a subset of INVs are ATG9A vesicles. This places ATG9A vesicles in a broader superfamily of trafficking vesicles.