Issues

Summary: This Review discusses new insights and technological advances in understanding how the nucleus contributes to the ability of the cell to translate mechanical stimuli into transcriptional responses and establish a mechanical memory.

Highlighted Article: The Drosophila atypical cadherin Ds is essential for epithelial wound closure, influencing cell shape changes and rearrangements and tissue mechanics, with occluding junctions regulating its subcellular localization.

Summary: Mis4, which acts as a cohesin loader during mitosis, is also required for exit from quiescence. mis4-450 mutants fail to maintain viability at quiescence (G0) and exhibit a dikaryon-like phenotype when resuming mitosis after passage of G0.

Summary: The non-canonical SMO axis that controls metabolism affects the condensation of the RNA-binding protein Smaug. The rapid dissolution of Smaug biomolecular condensates provides a mechanism for translational responses downstream of SMO-AMPK.

Summary: The intracellular localization and autophagy-dependent regulation of PBs is unclear. We find that PBs are present at ER–mitochondria contact sites (ERMCSs). Disruption of ERMCSs leads to autophagy-dependent PB loss via the Ca²⁺-CaMKK2-AMPK pathway.

Highlighted Article: Intrinsically disordered regions of the Sed4 ER membrane protein family and the cytosolic proteins Sec16 and Atg13 localize to tubules when imported into the ER lumen, suggesting their ability to sense specific features of the tubular lumen.

Highlighted Article: Novel actin-enriched cortical structures that contain cadherin-based cell–cell junctional components, despite not locating at cell–cell junctions are present in ground-state mouse embryonic stem cells.

Summary: The cytoplasmic dynein motor complex has a role on the postsynaptic side of glutamatergic neuromuscular junctions that influences both the structural organization and physiology of the neuromuscular junction.