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Cover image
Cover Image
Cover: A dense network of nerves and vasculature enables adipose tissue to rapidly respond to varying nutrient conditions, thereby ensuring whole-body metabolic flexibility. The three-dimensional rendering, generated in Blender, shows a cleared mouse inguinal white adipose tissue depot stained for sympathetic neurons (white) and blood vessels (red) using anti-tyrosine hydroxylase and anti-CD31 antibodies, respectively. See article by T. Rauchenwald et al. (jcs263438).
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RESEARCH HIGHLIGHTS
EDITORIAL
A century through the lens of Journal of Cell Science
Summary: Journal of Cell Science's publisher, The Company of Biologists, is celebrating its 100th birthday in 2025. Here, we review JCS's history since being founded as the Quarterly Journal of Microscopical Sciences.
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Diversity of microtubule arrays in animal cells at a glance
Summary: We provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
REVIEW
Actin from within – how nuclear myosins and actin regulate nuclear architecture and mechanics
Summary: A review of how nuclear actin and myosins regulate nuclear shape and mechanics through intranuclear organisation, chromatin remodelling and nuclear mechanopathways, which has significant implications in cell adaptation and pathology.
SHORT REPORT
Rab10 function in tubular endosome formation requires the N-terminal K3 residue and is disrupted by N-terminal tagging
Summary: N-terminal tagging is not always suitable for use in functional studies of Rab proteins. The Rab10 protein with an N-terminal tag is unable to support tubular endosome formation in RAB10-KO cells.
RESEARCH ARTICLES
Cadherins and growth factor receptors – ligand-selective mechano-switches at cadherin junctions
Homotypic, but not heterotypic, cadherin binding cooperates with growth factor receptors to unlock cadherin mechanotransduction cascades and reinforce cell adhesion.
Nuclear blebs are associated with destabilized chromatin-packing domains
Nuclear blebs are linked to various pathologies, including cancer and premature aging disorders. We investigate alterations in higher-order chromatin structure within blebs, revealing fragmentation of nanoscopic heterochromatin domains.
Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss
DNA and lamin B levels in nuclear blebs were measured to determine the best identifying marker; loss of DNA density is a constant for all nuclear blebs across cell type and perturbation whereas lamin B levels vary.
Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression
Summary: GLI2 and the repressor form of GLI3 counterregulate osteogenic differentiation of mesenchymal stem cells via Gli1 expression. GLI1 upregulates Gli1 itself and Gli2, constituting a positive feedback loop.
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease
Summary: The non-canonical Wnt/PCP pathway, specifically the ROR2 receptor, has a role in Alzheimer's disease mediated by Aβ-induced synaptic dysfunction by activating JNK signalling.
A protein interaction map of the myosin Myo2 reveals a role for Alo1 in mitochondrial inheritance in yeast
Alo1 is a newly identified mitochondrial outer membrane component that supports Myo2-dependent transport of mitochondria in yeast. It is particularly important for mitochondrial inheritance under increased oxidative stress.
TOOLS AND RESOURCES
Clearing the path for whole-mount labeling and quantification of neuron and vessel density in adipose tissue
Summary: A presentation of a whole-mount WAT clearing method that does not require tissue perfusion and expands the usable antibody portfolio. TiNeQuant is presented as an automated tool for 3D quantification of network density.
FIRST PERSON
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
