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Volume 138, Issue 20
October 2025
Journal of Cell Science Cover Image for Volume 138, Issue 20
All issues
ISSN 0021-9533
EISSN 1477-9137
In this issue

Special Issue: Cilia and Flagella: from Basic Biology to Disease

First person – Daniel Abbühl
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RESEARCH ARTICLES

REVIEW COMMONS TRANSFER
A novel approach to tagging tubulin reveals microtubule assembly dynamics of the axoneme in Trypanosoma brucei
Daniel Abbühl,Martina Pružincová,Luděk Štěpánek,Eleonore Bouscasse,Rita Azevedo,Mariette Matondo,Vladimir Varga,Serge Bonnefoy,Philippe Bastin

Summary: The grow-and-lock model with a twist: cell cycle-dependent regulation of tubulin addition in the Trypanosoma brucei flagellum.

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SAXO proteins mediate tubulin turnover in axonemal microtubules of Chlamydomonas
Yongli Zhang,Xuecheng Li,Zhengmao Wang,Junmin Pan

Summary: SAXO proteins stabilize axonemal microtubules by reducing tubulin turnover to regulate ciliary length and assembly, without affecting ciliary motility.

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Skeletal ciliopathy variants of the dynein-2 DYNC2LI1 subunit impair osteogenic differentiation of mesenchymal stem cells
Yamato Ishida,Haruka Hoshi,Kenichi Kawano,Hye-Won Shin,Yohei Katoh,Kazuhisa Nakayama

Summary: Skeletal ciliopathy variants of the dynein-2 subunit DYNC2LI1 impair osteogenic differentiation of mesenchymal stem cells owing to defects in retrograde ciliary protein trafficking, resulting in defects in Hedgehog signaling.

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β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and intraflagellar transport machinery
Taiju Fujii,Norihito Murai,Shinya Aso,Hiroyuki Takatsu,Hye-Won Shin,Yohei Katoh,Kazuhisa Nakayama

Summary: β-Arrestin plays crucial roles in the export of ciliary GPCRs. By connecting the BBSome and GPR161, β-arrestin mediates the export of GPR161 from cilia upon Hedgehog signaling activation.

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Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling
Rachel Bear,Steven A. Sloan,Tamara Caspary

Summary: Cilia play a direct role in regulating the Sonic hedgehog pathway in developing astrocytes, revealing novel functions for ciliary signaling during astrocyte proliferation and morphological development.

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Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal
Mengmeng Zhou,Yuhong Han,Jin Jiang

Summary: In response to Shh stimulation, Ulk4 undergoes phosphorylation-dependent SUMOylation, which promotes its condensation at ciliary tip to transduce Shh signal.

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FIRST PERSON

First person – Yongli Zhang and Xuecheng Li
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Accepted manuscripts
Syntaxin-2 balances phagocytic uptake and phagolysosomal clearance in macrophages
Suman Samanta, Abhrajyoti Nandi, Rupak Datta, Subhankar Dolai
Human disease variants of KATNIP fail to support CILK1 activation and control of primary cilia
Evan H. Carpenter, Cheuk Ying Chu, Ana Limerick, David L. Brautigan, Zheng Fu
Transcriptional adaptation after deletion of Cdc42 in primary T cells
Adam M. Rochussen, Claire Y. Ma, Gillian M. Griffiths
The adhesion plaque mediates fluid discharge and duplication of the contractile vacuole complex in Trypanosoma cruzi
Ingrid Augusto, Wendell Girard Dias, Alejandra Schoijet, Guillermo Daniel Alonso, Veronica Jimenez, Wanderley de Souza, Kildare Miranda
RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells
Aranya Pal, Prabin Bawali, Abhisek Brahma, Smruti Ranjan Rana, Rakesh Mohapatra, Debashish Chakraborty, Indrajit Poirah, Supriya Samal, Smaran Banerjee, Duane T. Smoot, Hassan Ashktorab, Asima Bhattacharyya
More accepted manuscripts

JCS fast-track option

Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.

Special Issue – Cell Biology of Mitochondria

Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.

Save the date – Imaging Cell Dynamics

Journal of Cell Science Meeting 2026 Imaging Cell Dynamics Date: 11 – 14 May 2026 Venue: Montanyà Hotel, Catalonia, Spain. Register your interest

We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.

Origin and evolution of mitochondrial inner membrane composition

In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.

Resolution in super-resolution microscopy

Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.

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