Issues

Summary: Phagocytosis involves receptor-driven actin and membrane remodelling to engulf microbes and debris. The phagosome then matures for degradation, supporting both nutrition and immune responses.

Summary: Purified human proteins are used to define minimal modules for centrosome scaffold assembly and microtubule aster nucleation.

Summary: A cryo-electron microscopy structure of yeast Pex5 in complex with a cargo uncovers a novel binding interface.

Summary: A forward genetic screen in C. elegans identify the mitochondrial protein SLC-25A46 as a mitochondrial fusion factor that regulates a mitofusin ortholog.

Highlighted Article: Inhibition of class I p21-activated kinase activity leads to the constitutitive production of PI(3,4,5)P₃ at the plasma membrane and a dysregulation of the actin cytoskeleton.

Highlighted Article: The endosomal ubiquitin ligase RFFL associates with and primes mitochondria for PRKN recruitment, targets mitofusins for degradation and contributes to mitochondrial networks and lipid homeostasis.

Summary: A biophysical model demonstrates how cristae formation can drive mitochondrial shape changes, offering a new mechanism linking inner membrane remodeling to organelle shaping beyond fission and fusion.