Issues

Summary: An overview of the biological mechanisms regulating transendothelial and trans-pericyte leukocyte migration hotspots during inflammation, and exploration of the molecular pathways that safeguard vascular integrity by preventing vessel leakage throughout this process.

Summary: This Hypothesis article proposes that key aspects of meiosis evolved prior to mitosis in ancestral eukaryotes.

Summary: Using mathematical models constrained by experimental data, we demonstrate quantitatively that the same cue-driven circuit organizes the cell cortex during polarization and cytokinesis.

Highlighted Article: Cells require both glutamine and glucose to form SGs and to maintain normal cell function during nutrient stress.

Summary: The intra-Golgi Golgin PpSgm1 mediates Golgi cisternal stacking in the budding yeast Pichia pastoris by collaborating synergistically with the GRIP domain Golgin PpImh1 in the cisternal stacking process of the Golgi.

Summary: Expression of LCN2 is elevated in invasive colorectal cancer. We demonstrate that LCN2 promotes invasion by stimulating the formation of focal adhesions by promoting c-Src activation.

Highlighted Article: In this study, we developed a novel auxin-inducible degron-based Rab27 trapper (named AID–2×RBD27) that can reversibly inhibit the function of Rab27A in melanosome transport in melanocytes.

Summary: Spatial intensity distribution analysis allows quantitative description of protein accumulation in DNA repair foci based on confocal images.