Issues

Summary: We summarize the key structural and functional features of vertebrate tight junctions, and the mechanisms and regulation of the tight junction barrier in physiology and pathology.

Summary: We review current knowledge of how pexophagy, the selective degradation of peroxisomes, is induced and regulated in mammalian cells, and discuss remaining gaps in the understanding of this pathway.

Summary: Caskin2 interacts with talin via a C-terminal LD motif, and with the SH3 domain of Abi1 via its proline-rich region. The Caskin2–Abi1 interaction functions to regulate cell motility.

Summary: Tbl1 translocates from the cytoplasm into the nucleus in association with β-catenin and functions as an adaptor to promote degradation of the Tcf7l1 protein.

Highlighted Article: The BAF complex subunit DPF3 localizes to centriolar satellites in interphase and to the spindle midzone and the midbody during mitosis, and has dual functions in mitosis and primary ciliogenesis.

Highlighted Article: V-ATPase assembly and RILP mediate hyperactivation of the small GTPase Rab7 when the late endosomal pH gradient collapses, disrupting endosome tubulation and CI-M6PR trafficking.

Highlighted Article: Analyzing neurons at different developmental stages reveals a role for γ-TuRCs in many aspects of dendrite arbor development and a more specific role for augmin in high-order dendritic branching.

Highlighted Article: During neuronal development augmin stimulates microtubule nucleation and is required in vivo in Drosophila c4da neurons to fine-tune their complex dendrite morphology.

Summary: Generation of the ARF family interactome allowed the attribution of potential localizations and functions to previously understudied members. ARL14 was found to activate PLD1 and contribute to ESCPE-1-mediated trafficking.