Issues

Summary: A review of the different types of membrane-associated clathrin assemblies observed by electron microscopy in various cell types and how the structural plasticity of clathrin contributes to its functional diversity.

Summary: A discussion of how increasing or decreasing matrix rigidity influences directional cell migration, referred to as durotaxis, and description of techniques and computational models that have been used to explore this relationship.

Highlighted Article: In contrast to predictions based on mammalian systems, members of the plant dynamin-related protein 2 family are recruited to the site of clathrin-mediated endocytosis independently of BAR-SH3 proteins.

Summary: Intraflagellar transport (IFT) is required for the function of primary cilia. Centrosomal protein 170 (CEP170) interacts with the IFT motor dynein-2, and loss of CEP170 causes defects in dynein-2 assembly and cilia function.

Highlighted Article: Despite opposite effects on microtubule dynamics, shifting the balance of microtubule tyrosination and detyrosination in either direction results in surprisingly similar defects in axonal organelle transport.

Highlighted Article: DLC1 inhibits basal Rho signaling to provide negative feedback for YAP activity during collective migration and sprouting angiogenesis.

Summary: By modulating the phosphorylation of Drp1, GTPBP8 influences mitochondrial fission dynamics and contributes to the overall maintenance of mitochondrial homeostasis.

Highlighted Article: We show that MCT4 and CD147 colocalize with MMP14 at invadopodia and intracellular sites of ECM degradation, and favor breast cancer cell invasion by stimulating ECM degradation.

Summary: CSL transcription factors regulate a diverse set of processes, but the mechanisms are not always clear. We show that S. pombe CSL proteins need the ability to bind DNA for most of their roles.

Summary: Aβ peptide enhances lipid raft-dependent endocytosis of GluA1 during induction of long-term potentiation: a novel mechanism of hippocampal long-term potentiation dysfunction in Alzheimer's disease.