Issues

Summary: A discussion of how nuclear actin dynamics have emerged as an integral component of the nucleoskeleton, regulating nuclear organization, gene expression and genome integrity.

Summary: To study the intricate metabolic network of sphingolipids, minimally modified probes are the tools of choice. We review progress made by using these probes together with the power of click chemistry.

Highlighted Article:C. elegans male meiosis II exhibits abridged spindle checkpoint pathway and its progression is independent of proteasome activities, whereas male meiosis I responds weakly to the spindle checkpoint.

Highlighted Article: Exploration of the activities of myoblasts over a range of substrate stiffnesses and extracellular matrix components to understand their effects on myoblast contractility, which was found to be linked to proliferation.

Highlighted Article: Cell junctions link cells and anchor the cytoskeleton. Here, we define the role in this process of the conserved Dilute domain in the complex multidomain Canoe protein (a homolog of afadin).

Summary: Quantitative dynamic analysis of neuronal growth cone filopodia formation reveals a density-dependent interaction between the membrane adaptor TOCA-1 and actin filament elongating protein Ena.

Highlighted Article: Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, leads to decreased nucleosome stability, impaired heterochromatin formation, and defective differentiation in mouse ESCs.

Highlighted Article: The conserved fly proteolipid protein M6 is palmitoylated on cytoplasmic cysteine residues to promote localization at cell vertices, where M6 is required for assembly of tricellular occluding junctions.

Summary: This study unlocks a key link between cellular stress and signaling, paving the way for targeted treatment of systemic and neurological diseases.