Issues

Summary: Researchers working on cell and tissue polarity across scales share their thoughts on unique, emerging or open questions relating to their field.

Summary: A review highlighting the intersecting dynamics of polarity proteins, fate determinants, cortical actin and plasma membrane morphology throughout the cell cycle of Drosophila neural stem cells.

Summary: This Cell Science at a Glance article provides basic knowledge and the latest findings on the mechanism of zygote polarization in Arabidopsis thaliana as obtained through live-imaging analysis of the zygote.

Summary: Review of the molecular alterations associated with inverted apicobasal polarity and their consequences in health and disease.

Summary: In this Review, we delve into the occurrence of asymmetric cell division in cancer cells, assessing how this phenomenon contributes to cancer heterogeneity.

Summary: The Rac-GEF TIAM-1 promotes contralateral migration via its GEF domain, whereas its N-terminal domains suppress ectopic filiform protrusions around the periphery during mediolateral intercalation of dorsal epidermal cells in the Caenorhabditis elegans embryo.

Summary: There is an interplay between integrin-based adhesion and adherens junctions that regulates actin polarization and dynamics during the collective cell movements that drive wound healing in the Drosophila embryonic epidermis.

Summary: Cdc42 plays a key role in establishing a single axis of cell polarization. In budding yeast, Cdc42 couples septin recruitment to the axial landmark via Axl2, a landmark protein.

Summary: The transmembrane mucin MUC13 reduces intestinal barrier function by negative regulation of epithelial tight junction strength via protein kinase C.

Summary: Steroid hormone signaling coordinates adhesion, polarity and membrane contractility in collectively migrating border cells. This regulates functional protrusion dynamics, enabling timely migration.

Summary: PALS1 has a crucial role in coupling of the elongation of tight junction protein condensates with F-actin polymerization at the junctional area of epithelial cells.

Summary: The mitotic kinase Polo-like kinase 1 promotes centrosome polarization to the immune synapse in cytotoxic T cells by coupling TCR signaling to microtubule dynamics.

Summary: The adaptor protein-1 (AP-1) isoforms AP-1A and AP-1B govern the apico-basolateral trafficking polarities of the homologous copper-ATPases ATP7A and ATP7B at the trans-Golgi network.

Summary: In this study, we identify a plasma membrane-mediated mechanism that maintains epithelial cell identity to ensure correct execution of polarised cell divisions, genome maintenance and safeguard tissue integrity.

Summary: Crb3 could cooperate with Ezrin and Rab11a to allow basal body migration and construction of the apical actin meshwork of multicilated cells in Xenopus embryos.

Summary: There is a central role for epithelial polarity in controlling cell homeostasis via an impact on the membrane potential.

Summary: CdaH, a conserved Fused kinase, acts at multiple stages and scales to generate a pattern of cortical organelles during cell division in the ciliate Tetrahymena thermophila.

Summary: In the migrating follicular epithelium of Drosophila, trailing edge-enriched Fat2 concentrates Lar and Sema5c in trans at leading edges; they then act in parallel to promote collective migration.

Summary: Loss of HOPS-mediated lysosomal fusion indirectly blocks apical actin clearing and ciliogenesis in polarized epithelia by trapping Rab19 on late endosomes and depleting Rab19 from the basal body.

Summary: The junctional protein CGNL1 controls the localization of CAMSAP3 at apical epithelial junctions, as well as the organization of microtubules and the polarized architecture of epithelial cells in vitro and in vivo.

Summary: A method to culture trophoblast organoids (TOs) derived from human placental tissue that recapitulates the cellular orientation of chorionic villi in vivo, thus allowing for studies of placental biology under physiological conditions.