Issues

Summary: In this Review, we outline key early steps of primary ciliogenesis, focusing on several novel mechanisms for removal of CP110. We also highlight examples of ciliopathies caused by genetic variations in genes that encode key proteins involved in the early steps of ciliogenesis.

Summary: This Review discusses advances in our understanding of the role of autophagy during cellular reprogramming by drawing comparisons between plant and animal studies.

Highlighted Article: Interactomics analysis of ATG9A uncovers lipid transport and homeostasis proteins as major hits, leading to the characterization of the ATG9A–VPS13A complex.

Highlighted Article: Microglia, brain-resident macrophages, require the endolysosomal Cl⁻ transporter ClC-7 for effective clearance of debris.

Highlighted Article: Structure-based engineering uncovers functional differences for a protein complex: two types of yeast TORC1 have distinct functions.

Highlighted Article: The intracellular protease calpain-2 modulates neurogenesis of adult neural stem and progenitor cells of the mouse forebrain through cleavage of the neuronal transcription factor MEIS2.

Summary: To evade phagocytic killing, some pathogens puncture phagosomes using pore-forming toxins. Here, we delineate how pore formation dynamics dictate modes of host–pathogen interaction in the intracellular space and govern microbial fate.

Highlighted Article: AGS3 assembles into distinct biomolecular condensates in response to cell stress, and this assembly is selectively regulated by AGS3-binding partners involved in signal transduction within the cell.

Summary: The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF, Git and Arf79F, and the inhibition of the V-ATPase.

Summary: filoVision is a filopodia analysis platform that uses deep learning and tip markers to measure filopodia, prioritizing automation and flexibility for user data.