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RESEARCH HIGHLIGHTS

CELL SCIENTISTS TO WATCH

OPINION

Summary: When conducting live-cell imaging, it is important to balance sample health with image quality. AI technology can help achieve this balance, allowing for reactive and gentle imaging.

REVIEW

Summary: We review the role of molecular motors in autophagic flux, focusing on interactions and post-translational modifications, and we discuss how dysregulation of motor activity in autophagy contributes to disease.

SHORT REPORTS

Highlighted Article: RiboMeth-seq profiling of primary human dermal fibroblasts reveals growth arrest-specific patterns of rRNA 2′-O-methylation, which can distinguish and potentially influence specific growth phenotypes.

Summary: Collagen VI, a pivotal extracellular regulator of muscle homeostasis, counteracts myogenic differentiation and sustains stemness by modulating intracellular signals involved in myogenesis.

Highlighted Article: By using the human iPSC system to study neutrophil motility, we show that the actin regulator ARPC1B in both neutrophils and endothelium drives neutrophil motility.

RESEARCH ARTICLES

Summary: A GCN5–DNA-PKcs–TOP2B transcriptional regulatory axis underlies anthracycline resistance in acute myeloid leukemia, identifying DNA-PKcs as a therapeutic target for such acquired resistance.

Summary: Combining modelling and experimentation, we propose a latching-gate mechanism for strict alternation of DNA replication and mitosis in human cells and show that, if the latches are broken by mutation, then endocycles ensue.

Summary: The polyglutamylase TTLL1 acts selectively on microtubule doublets of the flagellar axoneme in T. brucei and TTLL1 deletion indicates crosstalk between tubulin tyrosination/detyrosination and polyglutamylation.

Summary: Expression of neuropsin and cleavage of its substrate L1CAM correlate with synaptogenesis during mouse hippocampus development. Neuropsin also regulates L1CAM transcription and thus facilitates synaptogenesis.

Highlighted Article: CCHCR1 differentially regulates the ER-to-Golgi transport, cell surface expression and signaling of two closely related G protein-coupled receptors and this sorting function is mediated through direct interaction.

Highlighted Article: Tethering of CENP-C or CENP-I induces CENP-A incorporation at a non-centromeric locus without Knl2, and further analyses suggest that CENP-C directly recruits HJURP for an artificial kinetochore formation.

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