CELL SCIENTISTS TO WATCH
Summary: When conducting live-cell imaging, it is important to balance sample health with image quality. AI technology can help achieve this balance, allowing for reactive and gentle imaging.
2′-O-ribose methylation levels of ribosomal RNA distinguish different types of growth arrest in human dermal fibroblasts
Highlighted Article: RiboMeth-seq profiling of primary human dermal fibroblasts reveals growth arrest-specific patterns of rRNA 2′-O-methylation, which can distinguish and potentially influence specific growth phenotypes.
Summary: Collagen VI, a pivotal extracellular regulator of muscle homeostasis, counteracts myogenic differentiation and sustains stemness by modulating intracellular signals involved in myogenesis.
Highlighted Article: By using the human iPSC system to study neutrophil motility, we show that the actin regulator ARPC1B in both neutrophils and endothelium drives neutrophil motility.
DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia
Summary: A GCN5–DNA-PKcs–TOP2B transcriptional regulatory axis underlies anthracycline resistance in acute myeloid leukemia, identifying DNA-PKcs as a therapeutic target for such acquired resistance.
Summary: Combining modelling and experimentation, we propose a latching-gate mechanism for strict alternation of DNA replication and mitosis in human cells and show that, if the latches are broken by mutation, then endocycles ensue.
Microtubule polyglutamylation is an essential regulator of cytoskeletal integrity in Trypanosoma brucei
Summary: The polyglutamylase TTLL1 acts selectively on microtubule doublets of the flagellar axoneme in T. brucei and TTLL1 deletion indicates crosstalk between tubulin tyrosination/detyrosination and polyglutamylation.
Summary: Expression of neuropsin and cleavage of its substrate L1CAM correlate with synaptogenesis during mouse hippocampus development. Neuropsin also regulates L1CAM transcription and thus facilitates synaptogenesis.
Highlighted Article: CCHCR1 differentially regulates the ER-to-Golgi transport, cell surface expression and signaling of two closely related G protein-coupled receptors and this sorting function is mediated through direct interaction.
Artificial tethering of constitutive centromere-associated network proteins induces CENP-A deposition without Knl2 in DT40 cells
Highlighted Article: Tethering of CENP-C or CENP-I induces CENP-A incorporation at a non-centromeric locus without Knl2, and further analyses suggest that CENP-C directly recruits HJURP for an artificial kinetochore formation.