Issues

Summary: We discuss the evolution and mechanisms of chromatin externalisation and (patho)physiological functions of extracellular histones, including a perspective on their potential to act as bioactive, cell modulatory factors.

Summary: Review discussing how phase separation of microtubule-binding proteins impacts their regulation of microtubule dynamics, and the significance for these mechanisms in neuronal development and brain diseases.

Highlighted Article: Phylogenetic profiling across holocentric or monocentric metazoans, combined with functional experiments in nematodes, supports an inverse relationship between kinetochore size and CENP-E dependence for chromosome alignment.

Summary: The protein kinase AMPK displays Golgi localization and mediates GBF1 phosphorylation and Golgi fragmentation, thus linking cellular energy homeostasis to protein secretion.

Summary: Yck1/2 kinases regulate Mss4 phosphorylation and localization and affect multiple components of the TORC2 network, influencing lesser-known aspects of this signaling.

Summary: Nanowires specifically targeting apical active or inactive integrins were used to determine that integrins differentially regulate tight junction morphology and epithelial barrier function depending on activation state.

Summary: Replication stress leads to therapy-induced senescence (TIS) induction in residual glioblastoma cells. These cells orchestrate a non-canonical replication stress response with ATR signaling to overcome TIS and relapse.

Highlighted Article: The endothelial cadherin complex mediates AMPK activation through recruitment of LKB1 to support actin cytoskeletal dynamics, increased glycolysis and vasodilation via increased eNOS activity.

Summary: The repression of a cell surface flocculin (Flo11p) in laboratory yeast strains is epigenetically maintained by the replication-coupled chromatin assembly pathway.

Highlighted Article: TXNDC15, also known as MKS14, an ER-localized thioredoxin-like transmembrane protein that is mutated in Meckel syndrome (MKS), contributes to the integrity of the MKS module in the ciliary transition zone.

Summary: miR-206 is expressed in chronically denervated muscles and muscles undergoing cycles of degeneration and regeneration. It targets transcripts of auxiliary and core proteins essential for AChR clustering.

Summary: Ankyrin-B plays a vital role in lens architecture, growth and function through its involvement in membrane protein and spectrin-actin cytoskeletal organization and stability.