Issues

Summary: The endoplasmic reticulum (ER) is comprehensively remodelled for mitosis. Altered composition, morphology and associations likely enable new mitotic functions of the ER, which are only starting to emerge.

Highlighted Article: In C. elegans embryos, PLK-1 targeted to the inner kinetochore by CENP-C has different functions from when recruited to the outer kinetochore by BUB-1.

Summary: The skin is exposed to ultraviolet radiation. Here, we show that UVB induces Wnt–β-catenin signaling that leads to downregulation of Dicer and a reduction in levels of microRNAs involved in melanocyte biology.

Highlighted Article: Contact sites between lysosomes and the ER are required for cellular lipid homeostasis. The lysosomal protein LIMP-2 (also known as SCARB2) forms membrane contact sites with the endosomal protein STARD3 and the ER-localized VAPB.

Highlighted Article: Stiff matrices promote transforming growth factor β1-induced epithelial–mesenchymal transition via regulation of nuclear localization of the transcription factor enhancer of zeste homolog 2.

Summary: HIV-1 Gag N-myristoylation is required for co-trafficking with late endosomes/lysosomes, altering their motility to drive virus assembly at virus-containing compartments in macrophages.

Summary: DRAK2 contributes to myosin light chain activation in T cells, impacting motility, T cell receptor microcluster accumulation and conjugation to antigen-presenting cells.

Highlighted Article: The ImmunoCellCycle-ID method offers a robust and user-friendly IF-based detailed cell cycle stage identification at a single-cell resolution and precision.