Issues

Summary: The vasculature facilitates leukocyte transit and cancer cell dissemination. This Review compares the vascular dissemination of leukocytes and circulating tumor cells (CTCs), highlighting their similarities and differences.

Summary: This Review highlights recent updates on how inflammation coordinates tissue homeostasis, regeneration and aging in epithelial tissues like the respiratory tract by regulating stem cells and their niches.

Highlighted Article: Yeast vacuole transport from mother cell to bud terminates in large buds through degradation of the myosin adaptor Vac17. The SPOC kinase Kin4 contributes to vacuole inheritance by preventing premature Vac17 degradation.

Summary: PROM1 variants are associated with inherited blindness. CRISPR knockdown of prom1 in frogs results in age-dependent retinal degeneration that involves retinal pigment epithelium dysfunction preceding photoreceptor death.

Highlighted Article: A mechanistic connection between microtubule stability, Ca²⁺ flux and cell morphology determines the cellular response to matrix rigidity.

Summary: The AP-3 adaptor in Saccharomyces cerevisiae has intrinsically disordered regions required for AP-3 vesicle budding from the Golgi. Without these hinges, AP-3 remains associated with Golgi compartments as they mature.

Summary: The microRNA-binding protein QKI plays a role in the inhibition of brain inflammation by inhibiting extracellular release of the mature microRNA let-7b and controlling its loading into extracellular vesicles.

Summary: A simple method using an out-of-the-box setup can be used to determine whether membrane-binding proteins are curvature sensitive or if they have any membrane-remodelling activity.

Summary: Our inducible expression system for fission yeast enhances control, offers compatibility with non-dividing cells, and enables synchronous meiosis induction and conditional loss-of-function analysis.