CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Highlighted Article: The atypical Rho GTPase RhoU self-associates via its C-terminal extension. This interaction increases activation of downstream p21-activated kinases and regulates cell morphology, constituting a new mechanism of Rho GTPase regulation.
Summary: A new method of cytosolic extraction with varying MT status is used to identify novel microtubule-associated proteins from proteomic analysis. Among these is the ubiquitin E3 ligase TRIM3.
Summary: Drosophila BicD and BicDR are needed for the elaboration of the F-actin bundles of macrochaetae and proper Rab6 and Spn-F expression. BicDR appears to support BicD in vesicle transport.
Highlighted Article: Two prominent monoubiquitylation sites on the actin polymerase VASP reduce the ability of VASP to bind, bundle and elongate actin filaments.
S100A11 promotes focal adhesion disassembly via myosin II-driven contractility and Piezo1-mediated Ca2+ entry
Summary: S100A11 transiently localizes to disassembling focal adhesions. S100A11 recruitment promotes focal adhesion disassembly and is driven by Ca2+ influx via actomyosin-mediated activation of Piezo1 channels.
Summary: HIV-1 p17, but not HIV-2 p17 or SIV p17, facilitates innate immune responses to cytosolic DNA via the p17–OLA1–STING axis. HIV-1 p17 interacts with OLA1 to inhibit the regulation of OLA1 on STING translocation and phosphorylation.