Issues

Summary: We present an overview of the current knowledge regarding matrix metalloproteinases, the regulation of their activity, and their trafficking pathways and target proteins, as well as their impact on health and disease.

Summary: This Review summarises the importance, challenges and approaches used for imaging and analysing actin organisation and dynamic behaviour in 3D samples.

Highlighted Article: The atypical Rho GTPase RhoU self-associates via its C-terminal extension. This interaction increases activation of downstream p21-activated kinases and regulates cell morphology, constituting a new mechanism of Rho GTPase regulation.

Summary: A new method of cytosolic extraction with varying MT status is used to identify novel microtubule-associated proteins from proteomic analysis. Among these is the ubiquitin E3 ligase TRIM3.

Summary: Drosophila BicD and BicDR are needed for the elaboration of the F-actin bundles of macrochaetae and proper Rab6 and Spn-F expression. BicDR appears to support BicD in vesicle transport.

Highlighted Article: Two prominent monoubiquitylation sites on the actin polymerase VASP reduce the ability of VASP to bind, bundle and elongate actin filaments.

Summary: S100A11 transiently localizes to disassembling focal adhesions. S100A11 recruitment promotes focal adhesion disassembly and is driven by Ca²⁺ influx via actomyosin-mediated activation of Piezo1 channels.

Summary: HIV-1 p17, but not HIV-2 p17 or SIV p17, facilitates innate immune responses to cytosolic DNA via the p17–OLA1–STING axis. HIV-1 p17 interacts with OLA1 to inhibit the regulation of OLA1 on STING translocation and phosphorylation.