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CELL SCIENCE AT A GLANCE

Summary: We overview recent insights into the diverse cellular mechanisms underlying erythroblast enucleation, which is the unique process by which mammalian red blood cells eliminate their nuclei.

REVIEW

Summary: We review mechanisms of assembly of the HIV-1 structural protein Gag from biophysical and biological perspectives, highlighting the requirement for host cell factors in viral particle assembly and budding.

SHORT REPORT

Highlighted Article: Tau and MAP6 play antagonistic roles in regulating multiple aspects of neuronal development, presumably via their antagonistic effects on microtubule dynamics.

RESEARCH ARTICLES

Highlighted Article: The RhoG GEF SGEF regulates the stability, turnover and transcription of E-cadherin and ZO-1 in epithelial cells in a process that involves endocytosis, β-catenin signaling and the transcriptional repressor Slug.

Summary: Lipid droplet number is reduced in cultures infected with Junín virus and in cells expressing only the viral nucleoprotein. Mechanistically, lipophagy is involved in LD virus-driven reduction, with the resulting fatty acids being substrates of fatty acid β-oxidation.

Summary: There is a decreased level of 5-HT1AR–5-HT7R heterodimerization in the prefrontal cortex of anhedonic mice, suggesting that heterodimerization has a role in development of stress resiliency.

Summary: NaV1.1, encoded by SCN1A, plays an important role in DNA replication during the S phase of the cell cycle of mesenchymal stem cells by regulating AKT and CDK2.

Summary: Development of a method to measure KIF1Bβ activity and detect disease abnormalities using C. elegans genetics and single-molecule analysis.

Highlighted Article: Analysis of the biochemical properties of the Drosophila kinesin protein UNC-104 reveals mutations that promote dimerization of UNC-104, implicating the function of the FHA domain in kinesin autoinhibition.

Highlighted Article: The cellular polarity of Toxoplasma is established very early. Arc forms of the apical polar ring and basal complex co-develop at opposite ends of the newly nucleated microtubules towards the centriole region.

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