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RESEARCH HIGHLIGHTS

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: An overview of the recent advancements in the field of IFs, exploring their general features, functions beyond structural support, and involvement in diseases.

REVIEW

Summary: A Review highlighting some of the mechanistic similarities and differences in CCV formation via CME from mammals, yeast and plants.

SHORT REPORT

Highlighted Article: N-terminal tags impair some functions of lamin A but not others, cautioning researchers who use tagged lamins to study the nucleus.

RESEARCH ARTICLES

Highlighted Article: Hyperosmotic stimuli induce reversible shortening and disassembly of primary cilia, with early diffusion of the pericentriolar material, by causing excessive formation of cytoplasmic microtubules and F-actin.

Summary: Investigation of the PHD finger proteins DevPF1 and DevPF2 indicates that they play crucial roles in genome reorganization in the ciliate Paramecium, potentially by regulating the coding and non-coding transcription during development.

Highlighted Article: Phagocytic uptake of R848-loaded protocells reprogrammes human macrophages in vitro, and in zebrafish, models of skin and skeletal repair drives macrophages to be pro-inflammatory and improves healing of infected wounds.

Summary: CRISPR/Cas9-mediated disruption of testis-enriched protein MYCBPAP results in immotile spermatozoa with short tails and male infertility in mice.

Summary: Translation of FEM1B mRNA continues beyond its stop codon to generate a C-terminally extended unstable isoform, and this process regulates the cell cycle.

TOOLS AND RESOURCES

Summary: A fast CRISPR-pipeline to endogenously tag proteins of interest with labeling enzymes on their C- and N-terminus; this was used to map the interactome of different adaptor protein complexes using TurboID.

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