Issues

Summary: A description of the distinct pathways and mechanisms of what is sometimes called ‘non-canonical autophagy’, highlighting the use of terms such as CASM, VAIL and STIL for ATG8 targeting of membranes in different contexts.

Summary: Actin polymer networks are essential to eukaryotic cell form and function. This Review highlights what we know about the evolution and diversification of actin networks.

Summary: Tob1 is a Pax7 target protein that negatively controls muscle stem cell population expansion; its ablation in mice boosts muscle regeneration.

Highlighted Article: We screened for compounds that were synthetic lethal with NF1 loss and identified BORC, a complex required for lysosome trafficking, as a promising therapeutic target for NF1-deficient tumors.

Summary: The small ARF-like GTPase TTN5 has unusual rapid nucleotide exchange activity. It is likely present in a GTP-loaded form in cells where it is linked with membrane dynamics and vesicle transport within the endomembrane system.

Highlighted Article: During cellular apical constriction in Drosophila tubulogenesis, a protein hub comprising β-H-Spectrin, Shot, Patronin, Filamin and Big bang forms at the interface of apical-medial actomyosin and microtubules.

Summary: The budding yeast 14-3-3 proteins Bmh1 and Bmh2 are essential for maintaining kinetochore integrity and proper chromosome congression, ensuring accurate chromosome segregation and cell cycle progression.

Highlighted Article: The topology of a membrane protein largely determines its localization in the early secretory pathway: type I proteins locate to the endoplasmic reticulum and type II proteins to the Golgi apparatus.

Summary: Dictyostelium discoideum cells use two proteins with similar phosphatase functions, each playing unique roles, possibly in dephosphorylating PI(3,4,5)P3 in different membrane areas, to mediate movement away from a chemorepellent.