Issues

Summary: This Review discusses the roles of tetraspanin proteins in membrane remodeling processes including membrane repair, membrane fusion and migrasome formation, as well as in disease, such as cancer.

Summary: Summary of 30 years of focal adhesion kinase (FAK) research with a view of the ongoing clinical testing of small-molecule FAK inhibitors.

Summary: Intracellular signaling by the endothelial TMEM16F lipid scramblase regulates angiogenesis. TMEM16F deficiency enhances Src activation, leading to VE-cadherin phosphorylation and downregulation, and angiogenic defects.

Highlighted Article: RhoA exhibits both stimulatory and inhibitory activities on axon formation depending on the timing, location and downstream effectors involved.

Summary: SETD3 is a protein modifier that regulates actin polymerization and mitochondrial dynamics in response to mechanical changes in the extracellular matrix.

Summary: The Sema6A intracellular domain is required for zebrafish retinal development, including Müller glia development and protection from cell death.

Summary: An N-terminal peptide with a specific amino acid composition and very few basic residues is sufficient for mitochondrial protein targeting in Cyanidioschyzon merolae.

Summary: TORC1-regulated proteasome assembly chaperone production is necessary for proteasome assembly and proteostasis. We identify Cell Wall Integrity and Sch9 signalling as mechanisms controlling this.

Highlighted Article: PTPRK canonically dephosphorylates tyrosine residues. Deletion in mice supports that it has a function in colon repair and tumour suppression. Use of a catalytic mutant reveals catalysis-independent roles.