Issues

Summary: A Review exploring how mechanical cues from the cellular microenvironment regulate immune cell activation, signaling and function, highlighting the crucial role of mechanical signals in modulating adaptive immunity.

Summary: During meiosis, chromosomes can become entangled or entrapped and subsequently form interlocks. Here, we review observations of interlocks and provide insights into mechanisms that resolve them.

Summary: An absolute quantification of the components of the IFT machinery in the Chlamydomonas whole cilium provides insights into the assembly of IFT trains and ciliary assembly.

Summary: CCG-1423-derived compounds are shown to be general transcription inhibitors, extending their potential applications from MRTF-SRF pathway to transcription research.

Highlighted Article: The retromer complex is selectively expanded in comparison to its anciently homologous retriever complex in the globally important parasite Trichomonas vaginalis and its relatives.

Highlighted Article: Assembly of an irregular contractile actomyosin network that drives secretion from large vesicles in Drosophila is a biphasic process that employs distinct thresholds of activated Rho1 GTPase for actin assembly and myosin II recruitment, and is mediated by RhoGEF2.

Highlighted Article: Constitutively active c-Src (Y527F) in 3D vascular models induces a ballooning phenotype due to local secretion of MMPs at focal adhesions in endothelial cells.

Highlighted Article: A novel role of CEP41 as a microtubule-associated protein that promotes microtubule assembly and regulates cell cycle progression offers insights into the development of ciliopathies.